An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.
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| Title: | An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration. |
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| Authors: | Honey MIJ; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Hok-A-Hin YS; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Thijssen EH; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Cousins KAQ; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., van der Weijden B; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., In 't Veld L; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Stoops E; ADx NeuroSciences, Ghent, Belgium., de Boer SCM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; The University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, New South Wales, Australia., Duits FH; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., de Houwer JFH; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Morrema THJ; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Alcolea D; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Illán-Gala I; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Fortea J; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Lleó A; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Boxer AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Irwin DJ; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shaw L; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McMillan CT; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wolk DA; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hoozemans JJM; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Nederland, Amersfoort, the Netherlands., van der Ende E; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Seelaar H; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Verberk IMW; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Gan L; Weill Cornell Medicine, Brain and Mind Research Institute, New York City, NY, USA., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands. c.teunissen@amsterdamumc.nl. |
| Source: | Nature medicine [Nat Med] 2026 Jun; Vol. 32 (6), pp. 2083-2095. Date of Electronic Publication: 2026 Apr 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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