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Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.

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Title: Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.
Authors: Li C; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Richards SM; Novartis Biomedical Research, Novartis Campus, Basel, Switzerland., Quinn G; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Abedini A; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhu M; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Verma T; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mohandes S; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pitts R; Novartis Biomedical Research, Cambridge, MA, USA., Barros V; Novartis Biomedical Research, Novartis Campus, Basel, Switzerland., Qiu X; Novartis Biomedical Research, Cambridge, MA, USA., Shin T; Novartis Biomedical Research, Cambridge, MA, USA., Loureiro JJ; Novartis Biomedical Research, Cambridge, MA, USA., Finkel N; Novartis Biomedical Research, Cambridge, MA, USA., Surapaneni A; Division of Precision Medicine, New York University School of Medicine, New York, NY, USA., Coresh J; Division of Precision Medicine, New York University School of Medicine, New York, NY, USA., Grams ME; Division of Precision Medicine, New York University School of Medicine, New York, NY, USA., Karihaloo A; Cardiorenal Division, R&ED, Novo Nordisk, Malov, Denmark., Li H; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Verma A; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Informatics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Ritchie M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division for Biomedical Informatics and AI, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dietrich WF; Novartis Biomedical Research, Cambridge, MA, USA., Jennings LL; Novartis Biomedical Research, Cambridge, MA, USA., Susztak K; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.
Corporate Authors: Penn Medicine BioBank
Source: Nature medicine [Nat Med] 2026 May; Vol. 32 (5), pp. 1701-1707. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Richards+SM%22">Richards SM</searchLink>; Novartis Biomedical Research, Novartis Campus, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Quinn+G%22">Quinn G</searchLink>; Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA.; 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Renal, Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Penn/CHOP Kidney Innovation Center, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ksusztak@pennmedicine.upenn.edu.
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