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Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.

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Title: Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.
Authors: Nielsen LK; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK., Frost JLI; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Vaughan DP; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Real R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Fumi R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Jensen MT; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Hodgson M; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Stafford EJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Wu L; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Ansorge O; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Quaegebeur A; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Imaging and Pathology, University of Leuven, Leuven, Belgium., Allinson KSJ; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Warner TT; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK., Jaunmuktane Z; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK., Misbahuddin A; Department of Neurology, Queen's Hospital, Romford, UK., Leigh PN; Department of Neuroscience, Brighton and Sussex Medical School, University of Brighton and University of Sussex, Brighton, UK., Ghosh BCP; Wessex Neurological Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK., Bhatia KP; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Church A; Department of Neurology, Royal Gwent Hospital, Newport, UK., Kobylecki C; Department of Neurology, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Hu MTM; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Rowe JB; Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Shomo AA; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA., Graham DL; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA., Mabrouk OS; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA., Morris HR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK., Sammler EM; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK., Jabbari E; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.
Source: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2026 Apr 15. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE
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  Data: Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.
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  Data: <searchLink fieldCode="AU" term="%22Nielsen+LK%22">Nielsen LK</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Frost+JLI%22">Frost JLI</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Vaughan+DP%22">Vaughan DP</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Real+R%22">Real R</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Fumi+R%22">Fumi R</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Jensen+MT%22">Jensen MT</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Hodgson+M%22">Hodgson M</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Stafford+EJ%22">Stafford EJ</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Ansorge+O%22">Ansorge O</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Quaegebeur+A%22">Quaegebeur A</searchLink>; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Imaging and Pathology, University of Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Allinson+KSJ%22">Allinson KSJ</searchLink>; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Warner+TT%22">Warner TT</searchLink>; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Jaunmuktane+Z%22">Jaunmuktane Z</searchLink>; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Misbahuddin+A%22">Misbahuddin A</searchLink>; Department of Neurology, Queen's Hospital, Romford, UK.<br /><searchLink fieldCode="AU" term="%22Leigh+PN%22">Leigh PN</searchLink>; Department of Neuroscience, Brighton and Sussex Medical School, University of Brighton and University of Sussex, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Ghosh+BCP%22">Ghosh BCP</searchLink>; Wessex Neurological Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Bhatia+KP%22">Bhatia KP</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Church+A%22">Church A</searchLink>; Department of Neurology, Royal Gwent Hospital, Newport, UK.<br /><searchLink fieldCode="AU" term="%22Kobylecki+C%22">Kobylecki C</searchLink>; Department of Neurology, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hu+MTM%22">Hu MTM</searchLink>; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rowe+JB%22">Rowe JB</searchLink>; Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Shomo+AA%22">Shomo AA</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Graham+DL%22">Graham DL</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mabrouk+OS%22">Mabrouk OS</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Morris+HR%22">Morris HR</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Sammler+EM%22">Sammler EM</searchLink>; Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Jabbari+E%22">Jabbari E</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.
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