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Alternative Rule-Out Cutoffs for a Novel High-Sensitivity Cardiac Troponin I Assay in Patients With Suspected Myocardial Infarction.

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Title: Alternative Rule-Out Cutoffs for a Novel High-Sensitivity Cardiac Troponin I Assay in Patients With Suspected Myocardial Infarction.
Authors: Durak K; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Lopez-Ayala P; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Koechlin L; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; Department of Cardiac Surgery University Hospital Zürich Switzerland., Boeddinghaus J; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; BHF Centre for Cardiovascular Science University of Edinburgh Scotland UK., De Vita F; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Kaplan E; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Herraiz-Recuenco L; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Miró Ò; GREAT Network Rome Italy.; Emergency Department Hospital Clinic Barcelona Catalonia Spain., Christ M; Emergency Department Kantonsspital Luzern Switzerland., Keller DI; Emergency Department University Hospital Zurich Switzerland., Martin-Sanchez JF; Emergency Department Hospital Clínico San Carlos Madrid Spain., Morawiec B; Second Department of Cardiology, Zabrze Medical University of Silesia Katowice Poland., Parenica J; Department of Cardiology University Hospital Brno Czechia.; Czech Republic and Medical Faculty Masaryk University Brno Czech Republic., Huré G; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Dinkel O; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Wildi K; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Bima P; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; Department of Medical Sciences University of Turin Italy., Glaeser J; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Spagnuolo C; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Mahfoud F; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland., Strebel I; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy., Mueller C; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.
Corporate Authors: APACE investigators
Source: Journal of the American Heart Association [J Am Heart Assoc] 2026 Apr 21; Vol. 15 (8), pp. e045517. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article; Multicenter Study; Validation Study
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alternative Rule-Out Cutoffs for a Novel High-Sensitivity Cardiac Troponin I Assay in Patients With Suspected Myocardial Infarction.
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  Data: <searchLink fieldCode="AU" term="%22Durak+K%22">Durak K</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Lopez-Ayala+P%22">Lopez-Ayala P</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Koechlin+L%22">Koechlin L</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; Department of Cardiac Surgery University Hospital Zürich Switzerland.<br /><searchLink fieldCode="AU" term="%22Boeddinghaus+J%22">Boeddinghaus J</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; BHF Centre for Cardiovascular Science University of Edinburgh Scotland UK.<br /><searchLink fieldCode="AU" term="%22De+Vita+F%22">De Vita F</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Kaplan+E%22">Kaplan E</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Herraiz-Recuenco+L%22">Herraiz-Recuenco L</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Miró+Ò%22">Miró Ò</searchLink>; GREAT Network Rome Italy.; Emergency Department Hospital Clinic Barcelona Catalonia Spain.<br /><searchLink fieldCode="AU" term="%22Christ+M%22">Christ M</searchLink>; 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Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Wildi+K%22">Wildi K</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Bima+P%22">Bima P</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.; Department of Medical Sciences University of Turin Italy.<br /><searchLink fieldCode="AU" term="%22Glaeser+J%22">Glaeser J</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Spagnuolo+C%22">Spagnuolo C</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Mahfoud+F%22">Mahfoud F</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.<br /><searchLink fieldCode="AU" term="%22Strebel+I%22">Strebel I</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.<br /><searchLink fieldCode="AU" term="%22Mueller+C%22">Mueller C</searchLink>; Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel University of Basel Switzerland.; GREAT Network Rome Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101580524 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2047-9980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220479980%22">20479980 </searchLink><i>NLM ISO Abbreviation: </i>J Am Heart Assoc <i>Subsets: </i>MEDLINE
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        Value: 10.1161/JAHA.125.045517
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