SZQ-3, a Novel Synthetic Chromone-Maleimide Hybrid Targeting NF-κB, Prevents Postmenopausal Osteoporosis by Modulating Mitochondrial Function in Bone Cells.

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Title: SZQ-3, a Novel Synthetic Chromone-Maleimide Hybrid Targeting NF-κB, Prevents Postmenopausal Osteoporosis by Modulating Mitochondrial Function in Bone Cells.
Authors: Zhang Y; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Jiang T; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Zhou R; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Tong W; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Ye H; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Tu J; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Yi M; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Ma X; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Chen S; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Ping Y; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Li B; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China., Chen Y; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China., Song Z; School of Pharmaceutical Sciences and State Key Lab Oratory of Macromolecular Drugs and Large-Scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Mao Y; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China., Huang S; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China., Zhao S; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2026 Apr 30; Vol. 40 (8), pp. e71749.
Publication Type: Journal Article
Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jiang+T%22">Jiang T</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tong+W%22">Tong W</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ye+H%22">Ye H</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tu+J%22">Tu J</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yi+M%22">Yi M</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ping+Y%22">Ping Y</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Song+Z%22">Song Z</searchLink>; School of Pharmaceutical Sciences and State Key Lab Oratory of Macromolecular Drugs and Large-Scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Mao+Y%22">Mao Y</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People's Republic of China.; Department of Oral Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
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        Value: 10.1096/fj.202502681RR
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        Text: English
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      – TitleFull: SZQ-3, a Novel Synthetic Chromone-Maleimide Hybrid Targeting NF-κB, Prevents Postmenopausal Osteoporosis by Modulating Mitochondrial Function in Bone Cells.
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