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Sex-specific genetic drivers of memory, executive functioning and language in older adults.

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Title: Sex-specific genetic drivers of memory, executive functioning and language in older adults.
Authors: Eissman JM; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Regelson AN; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Walters S; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Archer DB; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Durant A; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Lee ML; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Choi SE; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Scollard P; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Trittschuh EH; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA.; VA Puget Sound Health Care System, GRECC, Seattle, WA, 98108, USA., Mez J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA., Kang M; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; College of Pharmacy, Sookmyung Women's University, Seoul, 04310, Republic of Korea., Bush WS; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Gifford KA; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA., Bilgel M; Laboratory of Behavioral Neuroscience National Institute on Aging, Baltimore, MD, 21224, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63108, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Farrer LA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Vardarajan BN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, 10032, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Mayeux R; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, 10032, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Haines JL; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Kukull WA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Keene CD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA., Saykin AJ; Department of Radiology and Imaging Services, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, 46202, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Thompson PM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Albert MS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Johnson SC; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA., Engelman CD; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA., Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Resnick SM; Laboratory of Behavioral Neuroscience National Institute on Aging, Baltimore, MD, 21224, USA., Sperling RA; Department of Neurology, Harvard Medical School, Boston & Brigham and Women's Hospital, Boston, MA, 02115, USA.; Alzheimer's Disease Research Center, Massachusetts General Hospital, Charlestown, MA, 02129, USA., Crane PK; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Hohman TJ; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Dumitrescu L; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Source: Brain : a journal of neurology [Brain] 2026 Apr 16. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Eissman+JM%22">Eissman JM</searchLink>; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Regelson+AN%22">Regelson AN</searchLink>; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.<br /><searchLink fieldCode="AU" term="%22Walters+S%22">Walters S</searchLink>; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.<br /><searchLink fieldCode="AU" term="%22Archer+DB%22">Archer DB</searchLink>; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.<br /><searchLink fieldCode="AU" term="%22Durant+A%22">Durant A</searchLink>; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lee+ML%22">Lee ML</searchLink>; Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Choi+SE%22">Choi SE</searchLink>; Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Scollard+P%22">Scollard P</searchLink>; Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Trittschuh+EH%22">Trittschuh EH</searchLink>; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA.; VA Puget Sound Health Care System, GRECC, Seattle, WA, 98108, USA.<br /><searchLink fieldCode="AU" term="%22Mez+J%22">Mez J</searchLink>; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; College of Pharmacy, Sookmyung Women's University, Seoul, 04310, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bush+WS%22">Bush WS</searchLink>; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.<br /><searchLink fieldCode="AU" term="%22Kunkle+BW%22">Kunkle BW</searchLink>; John P. 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