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Circadian and Sleep-Related Polygenic Scores in Relation to Lithium Treatment Response in Bipolar Disorder.

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Title: Circadian and Sleep-Related Polygenic Scores in Relation to Lithium Treatment Response in Bipolar Disorder.
Authors: Zafrilla-López M; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain., Herrera-Escartín D; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain., Guardiola-Ripoll M; Hospital Universitari Institut Pere Mata (HUIPM), Institut d'Investigació Sanitària Pere Virgili (IISPV-CERCA), Reus, Spain., García-Fernández A; Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Barcelona Tech, Barcelona, Spain., Acosta-Díez M; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain., Giménez-Palomo A; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain., Saiz PA; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., García-Portilla MP; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., Jiménez E; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain., Papiol S; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Fañanás L; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain., Ruiz V; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain., Gavín P; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain., González-Blanco L; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., Vieta E; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Fatjó-Vilas M; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain., Benabarre A; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain, abenaba@clinic.cat.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain, abenaba@clinic.cat.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain, abenaba@clinic.cat.; Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, abenaba@clinic.cat., Mitjans M; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain.; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Sant Joan de Déu Research Institute (IR-SJD), Esplugues de Llobregat, Spain., Arias B; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, barbara.arias@ub.edu.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain, barbara.arias@ub.edu.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain, barbara.arias@ub.edu.
Source: Neuropsychobiology [Neuropsychobiology] 2026 Apr 16, pp. 1-10. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 7512895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0224 (Electronic) Linking ISSN: 0302282X NLM ISO Abbreviation: Neuropsychobiology Subsets: MEDLINE
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  Data: Circadian and Sleep-Related Polygenic Scores in Relation to Lithium Treatment Response in Bipolar Disorder.
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  Data: <searchLink fieldCode="AU" term="%22Zafrilla-López+M%22">Zafrilla-López M</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Herrera-Escartín+D%22">Herrera-Escartín D</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Guardiola-Ripoll+M%22">Guardiola-Ripoll M</searchLink>; Hospital Universitari Institut Pere Mata (HUIPM), Institut d'Investigació Sanitària Pere Virgili (IISPV-CERCA), Reus, Spain.<br /><searchLink fieldCode="AU" term="%22García-Fernández+A%22">García-Fernández A</searchLink>; Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Barcelona Tech, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Acosta-Díez+M%22">Acosta-Díez M</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Giménez-Palomo+A%22">Giménez-Palomo A</searchLink>; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Saiz+PA%22">Saiz PA</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22García-Portilla+MP%22">García-Portilla MP</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Papiol+S%22">Papiol S</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fañanás+L%22">Fañanás L</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz+V%22">Ruiz V</searchLink>; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gavín+P%22">Gavín P</searchLink>; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22González-Blanco+L%22">González-Blanco L</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Vieta+E%22">Vieta E</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schulze+TG%22">Schulze TG</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fatjó-Vilas+M%22">Fatjó-Vilas M</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Benabarre+A%22">Benabarre A</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain, abenaba@clinic.cat.; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clínic de Barcelona, Barcelona, Spain, abenaba@clinic.cat.; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain, abenaba@clinic.cat.; Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, abenaba@clinic.cat.<br /><searchLink fieldCode="AU" term="%22Mitjans+M%22">Mitjans M</searchLink>; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain.; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Sant Joan de Déu Research Institute (IR-SJD), Esplugues de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Arias+B%22">Arias B</searchLink>; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, barbara.arias@ub.edu.; CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain, barbara.arias@ub.edu.; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain, barbara.arias@ub.edu.
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