An opposing molecular gradient axis underlies primate cortical organization.

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Title: An opposing molecular gradient axis underlies primate cortical organization.
Authors: Huang Z; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; BGI Research, Hangzhou, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China., Yang Q; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Lingang Laboratory, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Li S; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; BGI Research, Hangzhou, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China., Zhu X; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Genetic Evolution and Animal Models, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China., Wang H; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Lin J; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China., Zhan Y; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Wu Y; BGI Research, Hangzhou, China., Wang Z; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Majka P; Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Warsaw, Poland., Qu H; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Atapour N; Neuroscience Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, VIC, Australia., Yang T; BGI Research, Hangzhou, China., Lin Y; BGI Research, Hangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China., Cui L; BGI Research, Hangzhou, China., Yao YG; State Key Laboratory of Genetic Evolution and Animal Models, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China., Liang Z; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Liu Z; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China., Li C; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Wei W; Lingang Laboratory, Shanghai, China., Zhou Y; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Ma S; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Shen Z; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China., Wei X; BGI Research, Hangzhou, China., Xu X; BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China., Liu S; BGI Research, Hangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China., Li C; Lingang Laboratory, Shanghai, China., Poo M; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China., Liu L; BGI Research, Hangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China., Rosa MGP; Neuroscience Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, VIC, Australia., Sun Y; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Key Laboratory of Precision Gene Editing and Clinical Translation, Shanghai, China., Hao S; BGI Research, Hangzhou, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China., Liu C; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.; Shanghai Key Laboratory of Child Brain and Development, Shanghai, China.
Source: Science (New York, N.Y.) [Science] 2026 Apr 16; Vol. 392 (6795), pp. eaea2673. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: An opposing molecular gradient axis underlies primate cortical organization.
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  Data: <searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; BGI Research, Hangzhou, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Lingang Laboratory, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; 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Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhan+Y%22">Zhan Y</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; 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BGI Research, Hangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yao+YG%22">Yao YG</searchLink>; State Key Laboratory of Genetic Evolution and Animal Models, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non-Human Primates, Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.<br /><searchLink fieldCode="AU" term="%22Liang+Z%22">Liang Z</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; 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Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shen+Z%22">Shen Z</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; BGI Research, Hangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.; 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Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Shanghai Key Laboratory of Precision Gene Editing and Clinical Translation, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hao+S%22">Hao S</searchLink>; BGI Research, Hangzhou, China.; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou, China.; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Institute of Neuroscience, State Key Laboratory of Genetic Evolution and Animal Models, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.; 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