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B lymphocyte protein factories produced by hematopoietic stem cell gene editing.

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Title: B lymphocyte protein factories produced by hematopoietic stem cell gene editing.
Authors: Hartweger H; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Ruprecht C; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Yao KH; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Laffont P; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Lima Dos Reis G; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Zhou P; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Hägglöf T; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Binet L; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Loewe M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Hong JP; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Xiao T; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, USA., Sefik E; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Hernandez B; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Gazumyan A; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Jankovic M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Costa G; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany., Nelson SA; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Clark J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kanatani S; Johns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, MD, USA., Wilson PC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria., Levashina EA; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany., Julien JP; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Wardemann H; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sinnis P; Johns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, MD, USA., Stamatatos L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Flavell RA; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Source: Science (New York, N.Y.) [Science] 2026 Apr 16; Vol. 392 (6795), pp. eadz8994. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: B lymphocyte protein factories produced by hematopoietic stem cell gene editing.
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  Data: <searchLink fieldCode="AU" term="%22Hartweger+H%22">Hartweger H</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ruprecht+C%22">Ruprecht C</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yao+KH%22">Yao KH</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Laffont+P%22">Laffont P</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lima+Dos+Reis+G%22">Lima Dos Reis G</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hägglöf+T%22">Hägglöf T</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Binet+L%22">Binet L</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Loewe+M%22">Loewe M</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hong+JP%22">Hong JP</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+T%22">Xiao T</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Sefik+E%22">Sefik E</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+B%22">Hernandez B</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gazumyan+A%22">Gazumyan A</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jankovic+M%22">Jankovic M</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Seaman+MS%22">Seaman MS</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Costa+G%22">Costa G</searchLink>; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nelson+SA%22">Nelson SA</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Clark+J%22">Clark J</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kanatani+S%22">Kanatani S</searchLink>; Johns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PC%22">Wilson PC</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Krammer+F%22">Krammer F</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Levashina+EA%22">Levashina EA</searchLink>; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Julien+JP%22">Julien JP</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wardemann+H%22">Wardemann H</searchLink>; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sinnis+P%22">Sinnis P</searchLink>; Johns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stamatatos+L%22">Stamatatos L</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Flavell+RA%22">Flavell RA</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nussenzweig+MC%22">Nussenzweig MC</searchLink>; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Apr 16; Vol. 392 (6795), pp. eadz8994. <i>Date of Electronic Publication: </i>2026 Apr 16.
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