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Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats.

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Title: Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats.
Authors: Wiltzsch V; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Dias DB; Julius Wolff Institute, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany., Schmidt JR; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany., Kirwan JA; Berlin Institute of Health at Charité -BIH Metabolomics, 10117, Berlin, Germany; University of Veterinary Medicine, Vienna, 1210, Vienna, Austria., Lehmann J; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany., Poh PSP; Julius Wolff Institute, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany., Kalkhof S; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany; Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany. Electronic address: stefan.kalkhof@izi.fraunhofer.de.
Source: Bone [Bone] 2026 Aug; Vol. 209, pp. 117901. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats.
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  Data: <searchLink fieldCode="AU" term="%22Wiltzsch+V%22">Wiltzsch V</searchLink>; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Dias+DB%22">Dias DB</searchLink>; Julius Wolff Institute, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+JR%22">Schmidt JR</searchLink>; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kirwan+JA%22">Kirwan JA</searchLink>; Berlin Institute of Health at Charité -BIH Metabolomics, 10117, Berlin, Germany; University of Veterinary Medicine, Vienna, 1210, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lehmann+J%22">Lehmann J</searchLink>; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Poh+PSP%22">Poh PSP</searchLink>; Julius Wolff Institute, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kalkhof+S%22">Kalkhof S</searchLink>; Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Leipzig, Germany; Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany. Electronic address: stefan.kalkhof@izi.fraunhofer.de.
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  Data: <searchLink fieldCode="JN" term="%228504048%22">Bone</searchLink> [Bone] 2026 Aug; Vol. 209, pp. 117901. <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8504048 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2763 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218732763%22">18732763 </searchLink><i>NLM ISO Abbreviation: </i>Bone <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bone.2026.117901
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      – Code: eng
        Text: English
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        StartPage: 117901
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      – TitleFull: Proteomic profiling links increased mast cell activity in regenerating callus to impaired scaffold-guided bone regeneration in diabetic rats.
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              Text: 2026 Aug
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              Y: 2026
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