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p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease.

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Title: p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease.
Authors: Salladay-Perez IA; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Avila I; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Estrada L; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Alexandru AC; Buck Institute for Research on Aging, Novato, CA, USA., Ponce C; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Dhingra A; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Torres G; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Deng CY; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Hegde R; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Gensheimer J; Molecular Biology Institute at UCLA, Los Angeles, CA, USA.; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Kale A; Buck Institute for Research on Aging, Novato, CA, USA., Heckenbach I; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Hui S; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Edillor C; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Soto JA; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Napior AJ; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Little I; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Larsen M; Molecular Biology Institute at UCLA, Los Angeles, CA, USA., Rose J; Buck Institute for Research on Aging, Novato, CA, USA., Farahi L; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lopez Gonzalez EDJ; Department of Diabetes & Cancer Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA., Krieger MR; Department of Chemistry and Biochemistry at UCLA, Los Angeles, CA, USA., Chowdhury K; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Sharma M; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Jiang Y; Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.; Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Williams K; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Koehler CM; Molecular Biology Institute at UCLA, Los Angeles, CA, USA.; Department of Chemistry and Biochemistry at UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, USA., Meyer JG; Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.; Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Mack JJ; Molecular Biology Institute at UCLA, Los Angeles, CA, USA.; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Brenner C; Department of Diabetes & Cancer Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA., Bensinger SJ; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Lagger C; Laboratory for Mechanistic Learning of Ageing Biology, Computer Science Department, Kyiv School of Economics, Kyiv, Ukraine., de Magalhães JP; Genomics of Ageing and Rejuvenation Lab, Department of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham, UK., Schilling B; Buck Institute for Research on Aging, Novato, CA, USA., Singh R; Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Comprehensive Liver Research Center at UCLA, Los Angeles, CA, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA, USA., Lusis AJ; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Covarrubias AJ; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. AJCovarrubias@mednet.ucla.edu.; Molecular Biology Institute at UCLA, Los Angeles, CA, USA. AJCovarrubias@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, CA, USA. AJCovarrubias@mednet.ucla.edu.; Comprehensive Liver Research Center at UCLA, Los Angeles, CA, USA. AJCovarrubias@mednet.ucla.edu.; Broad Stem Cell Research Center, University of California, Los Angeles, USA. AJCovarrubias@mednet.ucla.edu.
Source: Nature aging [Nat Aging] 2026 Apr; Vol. 6 (4), pp. 792-815. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: p21<superscript>+</superscript>TREM2<superscript>+</superscript> senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease.
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