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Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis.

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Title: Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis.
Authors: Vanegas-Avendano ND; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA., Chen H; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Wellmerling J; Department of Physiology & Biomedical Engineering. Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA., Rodriguez-Lopez J; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA., Ghobashi A; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Peters V; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA., Sen C; Children's Discovery and Innovation Institute, Broad StemCell Research Center, Jonsson Comprehensive Cancer Center, Departments of Pediatrics and Pulmonary Medicine, University of California, Los Angeles, California, USA., Reader BF; Human Tissue Biorepository. OSU Wexner Medical Center Comprehensive Transplant Center, The Ohio State University, Columbus, OH, USA., Shilo K; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Gomperts B; Children's Discovery and Innovation Institute, Broad StemCell Research Center, Jonsson Comprehensive Cancer Center, Departments of Pediatrics and Pulmonary Medicine, University of California, Los Angeles, California, USA., Ma Q; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Mora AL; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA., Tschumperlin DJ; Department of Physiology & Biomedical Engineering. Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA., Rojas M; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 10. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Vanegas-Avendano+ND%22">Vanegas-Avendano ND</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wellmerling+J%22">Wellmerling J</searchLink>; Department of Physiology & Biomedical Engineering. Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Lopez+J%22">Rodriguez-Lopez J</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ghobashi+A%22">Ghobashi A</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Peters+V%22">Peters V</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Sen+C%22">Sen C</searchLink>; Children's Discovery and Innovation Institute, Broad StemCell Research Center, Jonsson Comprehensive Cancer Center, Departments of Pediatrics and Pulmonary Medicine, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Reader+BF%22">Reader BF</searchLink>; Human Tissue Biorepository. OSU Wexner Medical Center Comprehensive Transplant Center, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Shilo+K%22">Shilo K</searchLink>; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Gomperts+B%22">Gomperts B</searchLink>; Children's Discovery and Innovation Institute, Broad StemCell Research Center, Jonsson Comprehensive Cancer Center, Departments of Pediatrics and Pulmonary Medicine, University of California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Q%22">Ma Q</searchLink>; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mora+AL%22">Mora AL</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Tschumperlin+DJ%22">Tschumperlin DJ</searchLink>; Department of Physiology & Biomedical Engineering. Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Rojas+M%22">Rojas M</searchLink>; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.
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