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Single nuclei/cell transcriptomics reveal DMD driven cell dynamics and mechanisms of fibroblast inflammatory tissue priming in human dystrophic muscle.

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Title: Single nuclei/cell transcriptomics reveal DMD driven cell dynamics and mechanisms of fibroblast inflammatory tissue priming in human dystrophic muscle.
Authors: Chesmore KN; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Barthélémy F; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Rengarajan S; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Scripture-Adams DD; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Sen A; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nasif D; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Little I; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Wang RT; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nieves-Rodriguez S; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Corona RI; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Steady N; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Yip A; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Douine ED; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nelson SF; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Miceli MC; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Source: Research square [Res Sq] 2026 Apr 08. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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  Data: Single nuclei/cell transcriptomics reveal DMD driven cell dynamics and mechanisms of fibroblast inflammatory tissue priming in human dystrophic muscle.
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  Data: <searchLink fieldCode="AU" term="%22Chesmore+KN%22">Chesmore KN</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barthélémy+F%22">Barthélémy F</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rengarajan+S%22">Rengarajan S</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Scripture-Adams+DD%22">Scripture-Adams DD</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sen+A%22">Sen A</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nasif+D%22">Nasif D</searchLink>; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Little+I%22">Little I</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RT%22">Wang RT</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nieves-Rodriguez+S%22">Nieves-Rodriguez S</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Corona+RI%22">Corona RI</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Steady+N%22">Steady N</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yip+A%22">Yip A</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Douine+ED%22">Douine ED</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+SF%22">Nelson SF</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miceli+MC%22">Miceli MC</searchLink>; Center for Duchenne Muscular Dystrophy at UCLA, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
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        Text: English
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