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Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.

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Title: Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
Authors: Chickering T; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Harp JM; Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, United States., Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., He G; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Hyde S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Ihlefeld A; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Janas M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., O'Flaherty DK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Schofield S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Szeto J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Theile CS; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Charissé K; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Jadhav V; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Maier MA; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States., Egli M; Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232, United States., Schlegel MK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 13; Vol. 54 (7).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
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