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Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.

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Title: Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.
Authors: Fan Y; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., De Silva S; Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tabassum NI; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Peng X; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Lim VJT; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Cheng X; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Datta KK; La Trobe University-Proteomics and Metabolomics Platform (LTU-PMP), La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Lowe R; La Trobe University-Proteomics and Metabolomics Platform (LTU-PMP), La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Johns TG; Epigenes Australia Pty Ltd, Melbourne, Australia., Mattson MP; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States., Mathivanan S; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Sobey CG; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; Centre for Cardiovascular Biology and Disease Research, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia., Okun E; The Paul Feder laboratory for Alzheimer's disease research at the Mina and Everard Goodman Faculty of Life Sciences, and the Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel., Liu YU; Laboratory for Neuroimmunology in Health and Disease, Center for Medical Research on Innovation and Translation, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China., Chen G; Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China., Lai MKP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea., Gunaratne J; Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Arumugam TV; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
Source: ELife [Elife] 2026 Apr 17; Vol. 14. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22De+Silva+S%22">De Silva S</searchLink>; Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tabassum+NI%22">Tabassum NI</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+VJT%22">Lim VJT</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Datta+KK%22">Datta KK</searchLink>; La Trobe University-Proteomics and Metabolomics Platform (LTU-PMP), La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Lowe+R%22">Lowe R</searchLink>; La Trobe University-Proteomics and Metabolomics Platform (LTU-PMP), La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Johns+TG%22">Johns TG</searchLink>; Epigenes Australia Pty Ltd, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Mattson+MP%22">Mattson MP</searchLink>; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.<br /><searchLink fieldCode="AU" term="%22Mathivanan+S%22">Mathivanan S</searchLink>; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Sobey+CG%22">Sobey CG</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; Centre for Cardiovascular Biology and Disease Research, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Okun+E%22">Okun E</searchLink>; The Paul Feder laboratory for Alzheimer's disease research at the Mina and Everard Goodman Faculty of Life Sciences, and the Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Liu+YU%22">Liu YU</searchLink>; Laboratory for Neuroimmunology in Health and Disease, Center for Medical Research on Innovation and Translation, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lai+MKP%22">Lai MKP</searchLink>; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Jo+DG%22">Jo DG</searchLink>; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Gunaratne+J%22">Gunaratne J</searchLink>; Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Arumugam+TV%22">Arumugam TV</searchLink>; Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Australia.; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
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