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Long-term follow up of opicapone as add-on to levodopa in Parkinson's patients without motor fluctuations.

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Title: Long-term follow up of opicapone as add-on to levodopa in Parkinson's patients without motor fluctuations.
Authors: Ferreira JJ; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade Lisboa, Lisbon, Portugal.; CNS - Campus Neurológico, Torres Vedras, Portugal., Rascol O; Clinical Investigation Centre CIC1436 Departments of Neurosciences and Clinical Pharmacology, Centre of Excellence for Neurodegeneration COEN NeuroToul, and NS-Park/FCRIN network; University of Toulouse 3, University Hospital of Toulouse, INSERM, Toulouse, France., Stocchi F; Department of Neurology, Institute for Research and Medical Care IRCCS San Raffaele, Roma, Italy.; Department of Neurology, San Raffaele University, Rome, Italy., Antonini A; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padova, Padova, Italy.; Department of Neurology, IRCCS San Camillo, Venice, Italy., Moreira J; BIAL - Portela & Ca S.A., Coronado, Portugal., Fonseca MM; BIAL - R&D INVESTMENTS, S.A, Porto, Portugal., Rocha JF; BIAL - Portela & Ca S.A., Coronado, Portugal., Brigas HC; BIAL - Portela & Ca S.A., Coronado, Portugal., Holenz J; BIAL - Portela & Ca S.A., Coronado, Portugal., Poewe W; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Corporate Authors: Epsilon Study investigators
Source: Journal of Parkinson's disease [J Parkinsons Dis] 2026 Jun; Vol. 16 (4), pp. 797-802. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Clinical Trial, Phase III; Journal Article; Letter; Randomized Controlled Trial
Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-term follow up of opicapone as add-on to levodopa in Parkinson's patients without motor fluctuations.
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  Data: <searchLink fieldCode="AU" term="%22Ferreira+JJ%22">Ferreira JJ</searchLink>; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade Lisboa, Lisbon, Portugal.; CNS - Campus Neurológico, Torres Vedras, Portugal.<br /><searchLink fieldCode="AU" term="%22Rascol+O%22">Rascol O</searchLink>; Clinical Investigation Centre CIC1436 Departments of Neurosciences and Clinical Pharmacology, Centre of Excellence for Neurodegeneration COEN NeuroToul, and NS-Park/FCRIN network; University of Toulouse 3, University Hospital of Toulouse, INSERM, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Stocchi+F%22">Stocchi F</searchLink>; Department of Neurology, Institute for Research and Medical Care IRCCS San Raffaele, Roma, Italy.; Department of Neurology, San Raffaele University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antonini+A%22">Antonini A</searchLink>; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padova, Padova, Italy.; Department of Neurology, IRCCS San Camillo, Venice, Italy.<br /><searchLink fieldCode="AU" term="%22Moreira+J%22">Moreira J</searchLink>; BIAL - Portela & Ca S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Fonseca+MM%22">Fonseca MM</searchLink>; BIAL - R&D INVESTMENTS, S.A, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Rocha+JF%22">Rocha JF</searchLink>; BIAL - Portela & Ca S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Brigas+HC%22">Brigas HC</searchLink>; BIAL - Portela & Ca S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Holenz+J%22">Holenz J</searchLink>; BIAL - Portela & Ca S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Poewe+W%22">Poewe W</searchLink>; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
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  Data: <searchLink fieldCode="CA" term="%22Epsilon+Study+investigators%22">Epsilon Study investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101567362%22">Journal of Parkinson's disease</searchLink> [J Parkinsons Dis] 2026 Jun; Vol. 16 (4), pp. 797-802. <i>Date of Electronic Publication: </i>2026 Apr 17.
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  Data: Clinical Trial, Phase III; Journal Article; Letter; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IOS+Press%22">IOS Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101567362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1877-718X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218777171%22">18777171 </searchLink><i>NLM ISO Abbreviation: </i>J Parkinsons Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41995421
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            – D: 01
              M: 06
              Text: 2026 Jun
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