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Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein.

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Title: Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein.
Authors: Varlow C; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Pees A; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Stehouwer JS; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA., Grotegerd AK; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany., Bleher D; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany., Guarino DS; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lindberg A; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Tong J; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Lopresti BJ; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA., Knight AC; Preclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA., Zabrocki M; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nasser A; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Shalgunov V; Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Ferri E; Health Innovative Products and Technologies (HIP-TECH) PhD Program, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Cannazza G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., McQuade P; Preclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA., Mathis CA; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA., Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Battisti UM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Herfert K; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany., Herth MM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Knudsen GM; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Vasdev N; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Source: Journal of Parkinson's disease [J Parkinsons Dis] 2026 Jun; Vol. 16 (4), pp. 683-698. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein.
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  Data: <searchLink fieldCode="AU" term="%22Varlow+C%22">Varlow C</searchLink>; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pees+A%22">Pees A</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stehouwer+JS%22">Stehouwer JS</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Grotegerd+AK%22">Grotegerd AK</searchLink>; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Bleher+D%22">Bleher D</searchLink>; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Guarino+DS%22">Guarino DS</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lindberg+A%22">Lindberg A</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tong+J%22">Tong J</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lopresti+BJ%22">Lopresti BJ</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Knight+AC%22">Knight AC</searchLink>; Preclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zabrocki+M%22">Zabrocki M</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nasser+A%22">Nasser A</searchLink>; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Shalgunov+V%22">Shalgunov V</searchLink>; Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ferri+E%22">Ferri E</searchLink>; Health Innovative Products and Technologies (HIP-TECH) PhD Program, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Cannazza+G%22">Cannazza G</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22McQuade+P%22">McQuade P</searchLink>; Preclinical and Translational Sciences - Imaging, Takeda Pharmaceutical Company, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mathis+CA%22">Mathis CA</searchLink>; Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mach+RH%22">Mach RH</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Battisti+UM%22">Battisti UM</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Herfert+K%22">Herfert K</searchLink>; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Herth+MM%22">Herth MM</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Knudsen+GM%22">Knudsen GM</searchLink>; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Vasdev+N%22">Vasdev N</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101567362%22">Journal of Parkinson's disease</searchLink> [J Parkinsons Dis] 2026 Jun; Vol. 16 (4), pp. 683-698. <i>Date of Electronic Publication: </i>2026 Apr 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IOS+Press%22">IOS Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101567362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1877-718X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218777171%22">18777171 </searchLink><i>NLM ISO Abbreviation: </i>J Parkinsons Dis <i>Subsets: </i>MEDLINE
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