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Efficacy and safety of early intravenous administration of tirofiban after thrombolysis in acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.

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Title: Efficacy and safety of early intravenous administration of tirofiban after thrombolysis in acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.
Authors: Spina E; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy. ema.spinaes@gmail.com.; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy. ema.spinaes@gmail.com., Spiezia AL; UOC Neurology and Stroke Unit, 'Ospedale del Mare', ASL Napoli 1 Centro, Naples, Italy., Pia FD; UOC Neurology and Stroke Unit, 'Ospedale del Mare', ASL Napoli 1 Centro, Naples, Italy., de Mase A; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Maurea C; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Servillo G; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Aramini S; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Ranieri A; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Barbato S; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Cuccurullo C; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Tozza S; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy., Esposito A; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy., Andreone V; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy., Manganelli F; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy., Candelaresi P; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.
Source: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of early intravenous administration of tirofiban after thrombolysis in acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.
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  Data: <searchLink fieldCode="AU" term="%22Spina+E%22">Spina E</searchLink>; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy. ema.spinaes@gmail.com.; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy. ema.spinaes@gmail.com.<br /><searchLink fieldCode="AU" term="%22Spiezia+AL%22">Spiezia AL</searchLink>; UOC Neurology and Stroke Unit, 'Ospedale del Mare', ASL Napoli 1 Centro, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Pia+FD%22">Pia FD</searchLink>; UOC Neurology and Stroke Unit, 'Ospedale del Mare', ASL Napoli 1 Centro, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22de+Mase+A%22">de Mase A</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Maurea+C%22">Maurea C</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Servillo+G%22">Servillo G</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Aramini+S%22">Aramini S</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ranieri+A%22">Ranieri A</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Barbato+S%22">Barbato S</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cuccurullo+C%22">Cuccurullo C</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Tozza+S%22">Tozza S</searchLink>; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Esposito+A%22">Esposito A</searchLink>; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Andreone+V%22">Andreone V</searchLink>; UOC Neurology and Stroke Unit, AORN 'A. Cardarelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Manganelli+F%22">Manganelli F</searchLink>; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.; Department of Neurosciences, Reproductive and Odontostomatology, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Candelaresi+P%22">Candelaresi P</searchLink>; UOC Neurology, Azienda Ospedaliera Universitaria 'Federico II', via Pansini 5, 80131, Napoli, Italy.
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