Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge.

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Title: Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge.
Authors: Makuyana N; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; MRC Laboratory of Molecular Biology, Cambridge, UK., Seldeslachts L; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Michiels L; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Burton OT; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Hernandez AR; Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Imperial College London, London, UK., Ghodsinia A; Department of Pathology, University of Cambridge, Cambridge, UK., Rahman E; National Heart & Lung Institute, Imperial College London, London, UK., Kops LM; Department of Pathology, University of Cambridge, Cambridge, UK., Singh K; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; Medical Cell Biology, Uppsala University, Uppsala, Sweden., Naranjo F; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Ali M; Department of Pathology, University of Cambridge, Cambridge, UK., Dashwood A; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Achkir M; Department of Pathology, University of Cambridge, Cambridge, UK., Kouser L; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Lienart S; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Guillaume S; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Naesens L; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium., Linterman MA; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; Malaghan Institute of Medical Research, Wellington, Aotearoa New Zealand., Wauters J; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium., Joulia R; National Heart & Lung Institute, Imperial College London, London, UK., Humblet-Baron S; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium., Vande Velde G; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Dooley J; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK., Liston A; Department of Pathology, University of Cambridge, Cambridge, UK.
Source: Science immunology [Sci Immunol] 2026 Apr 17; Vol. 11 (118), pp. eadv7969. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge.
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  Data: <searchLink fieldCode="AU" term="%22Makuyana+N%22">Makuyana N</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; MRC Laboratory of Molecular Biology, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Seldeslachts+L%22">Seldeslachts L</searchLink>; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Michiels+L%22">Michiels L</searchLink>; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Burton+OT%22">Burton OT</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hernandez+AR%22">Hernandez AR</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ghodsinia+A%22">Ghodsinia A</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rahman+E%22">Rahman E</searchLink>; National Heart & Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kops+LM%22">Kops LM</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; Medical Cell Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Naranjo+F%22">Naranjo F</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dashwood+A%22">Dashwood A</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Achkir+M%22">Achkir M</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kouser+L%22">Kouser L</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lienart+S%22">Lienart S</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Guillaume+S%22">Guillaume S</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Naesens+L%22">Naesens L</searchLink>; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Linterman+MA%22">Linterman MA</searchLink>; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.; Malaghan Institute of Medical Research, Wellington, Aotearoa New Zealand.<br /><searchLink fieldCode="AU" term="%22Wauters+J%22">Wauters J</searchLink>; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Joulia+R%22">Joulia R</searchLink>; National Heart & Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Humblet-Baron+S%22">Humblet-Baron S</searchLink>; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vande+Velde+G%22">Vande Velde G</searchLink>; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dooley+J%22">Dooley J</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Lymphocyte Signalling Department, Babraham Institute Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Liston+A%22">Liston A</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.
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