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A flexible and unified framework for single- and multi-outcome Mendelian randomization using summary statistics.

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Title: A flexible and unified framework for single- and multi-outcome Mendelian randomization using summary statistics.
Authors: Kang B; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Li D; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Xu K; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA., Chen J; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Feng S; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Wang J; Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Gao G; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Tasaki S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pierce BL; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Chen LS; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA. Electronic address: lchen4@bsd.uchicago.edu.
Source: American journal of human genetics [Am J Hum Genet] 2026 May 07; Vol. 113 (5), pp. 950-965. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kang+B%22">Kang B</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Feng+S%22">Feng S</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+G%22">Gao G</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Tasaki+S%22">Tasaki S</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pierce+BL%22">Pierce BL</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chen+LS%22">Chen LS</searchLink>; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA. Electronic address: lchen4@bsd.uchicago.edu.
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        Value: 10.1016/j.ajhg.2026.03.017
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              Text: 2026 May 07
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