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Antiretroviral therapy interferes with pseudovirus neutralization assays while Gag-specific T-cells influence mRNA vaccine outcomes in HIV patients.

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Title: Antiretroviral therapy interferes with pseudovirus neutralization assays while Gag-specific T-cells influence mRNA vaccine outcomes in HIV patients.
Authors: Litwin SM; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Trinh IV; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Bai S; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA., Sabino-Santos G; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Tong S; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Murrell AE; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Scott JC; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Chandra S; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Elliott DH; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Smira AR; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Meyers EL; Section of Infectious Diseases, Tulane University School of Medicine, New Orleans, LA, USA., Srinivasan S; Tulane University Newcomb-Tulane College, New Orleans, LA, USA., Francis M; Tulane University Newcomb-Tulane College, New Orleans, LA, USA., Goff KA; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA., Scheuermann SE; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA., Zwezdaryk KJ; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA., Maness NJ; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA., Karger AB; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Schieffelin JS; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Gunn BM; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA., Robinson JE; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA., Zheng CY; Section of Infectious Diseases, Tulane University School of Medicine, New Orleans, LA, USA., Norton EB; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA. enorton@tulane.edu.
Source: Scientific reports [Sci Rep] 2026 Apr 17; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Antiretroviral therapy interferes with pseudovirus neutralization assays while Gag-specific T-cells influence mRNA vaccine outcomes in HIV patients.
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  Data: <searchLink fieldCode="AU" term="%22Litwin+SM%22">Litwin SM</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Trinh+IV%22">Trinh IV</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Bai+S%22">Bai S</searchLink>; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sabino-Santos+G%22">Sabino-Santos G</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Tong+S%22">Tong S</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Murrell+AE%22">Murrell AE</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Scott+JC%22">Scott JC</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Chandra+S%22">Chandra S</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Elliott+DH%22">Elliott DH</searchLink>; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Smira+AR%22">Smira AR</searchLink>; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Meyers+EL%22">Meyers EL</searchLink>; Section of Infectious Diseases, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Srinivasan+S%22">Srinivasan S</searchLink>; Tulane University Newcomb-Tulane College, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Francis+M%22">Francis M</searchLink>; Tulane University Newcomb-Tulane College, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Goff+KA%22">Goff KA</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Scheuermann+SE%22">Scheuermann SE</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Zwezdaryk+KJ%22">Zwezdaryk KJ</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.<br /><searchLink fieldCode="AU" term="%22Maness+NJ%22">Maness NJ</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA.; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Karger+AB%22">Karger AB</searchLink>; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schieffelin+JS%22">Schieffelin JS</searchLink>; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Gunn+BM%22">Gunn BM</searchLink>; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+JE%22">Robinson JE</searchLink>; Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+CY%22">Zheng CY</searchLink>; Section of Infectious Diseases, Tulane University School of Medicine, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Norton+EB%22">Norton EB</searchLink>; Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112, USA. enorton@tulane.edu.
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