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Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation.

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Title: Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation.
Authors: Woo H; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea., Jang Y; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea., Kim S; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea., Kim W; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea., Zhang F; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China., Mall R; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar., Patel CN; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Kurera M; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Ngo C; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Jiang SH; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Nicotra A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France., Py BF; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France., Zheng M; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China. min.zheng@szbl.ac.cn., Man SM; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia. siming.man@anu.edu.au., Karki R; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea. rkarki@snu.ac.kr.; The Institute of Molecular Biology and Genetics (IMBG), Seoul National University, Seoul, Republic of Korea. rkarki@snu.ac.kr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2124-2151. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Woo+H%22">Woo H</searchLink>; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+Y%22">Jang Y</searchLink>; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Mall+R%22">Mall R</searchLink>; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Patel+CN%22">Patel CN</searchLink>; Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kurera+M%22">Kurera M</searchLink>; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Ngo+C%22">Ngo C</searchLink>; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Jiang+SH%22">Jiang SH</searchLink>; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Nicotra+A%22">Nicotra A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Py+BF%22">Py BF</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Zheng+M%22">Zheng M</searchLink>; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China. min.zheng@szbl.ac.cn.<br /><searchLink fieldCode="AU" term="%22Man+SM%22">Man SM</searchLink>; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia. siming.man@anu.edu.au.<br /><searchLink fieldCode="AU" term="%22Karki+R%22">Karki R</searchLink>; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea. rkarki@snu.ac.kr.; The Institute of Molecular Biology and Genetics (IMBG), Seoul National University, Seoul, Republic of Korea. rkarki@snu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2124-2151. <i>Date of Electronic Publication: </i>2026 Apr 17.
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              Text: 2026 Jun
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