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Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells.

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Title: Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells.
Authors: Chu NTL; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Dregval O; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Chang YW; Department of Physics, Gothenburg University, Gothenburg, Sweden., Kriukov E; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Tian X; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Liu X; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Trompet D; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Zhang MS; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; MOE Joint International Research Laboratory of Pancreatic Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li L; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Li Z; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ruiz EG; Department of Physics, Gothenburg University, Gothenburg, Sweden., Pereira JB; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Brittberg M; Cartilage Research Unit, Department of Orthopedics, University of Gothenburg, Gothenburg, Sweden., Barenius B; Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden., Sävendahl L; Department of Women and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Adams RH; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Gjertsson I; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden., Ohlsson C; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Unit of Clinical Pharmacology, Department of Pharmaceuticals, Sahlgrenska University Hospital, Gothenburg, Sweden., Volpe G; Department of Physics, Gothenburg University, Gothenburg, Sweden.; Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden., Chagin AS; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. andrei.chagin@gu.se.; Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden. andrei.chagin@gu.se.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells.
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  Data: <searchLink fieldCode="AU" term="%22Chu+NTL%22">Chu NTL</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Dregval+O%22">Dregval O</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Chang+YW%22">Chang YW</searchLink>; Department of Physics, Gothenburg University, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kriukov+E%22">Kriukov E</searchLink>; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Trompet+D%22">Trompet D</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhang+MS%22">Zhang MS</searchLink>; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; MOE Joint International Research Laboratory of Pancreatic Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ruiz+EG%22">Ruiz EG</searchLink>; Department of Physics, Gothenburg University, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Pereira+JB%22">Pereira JB</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Brittberg+M%22">Brittberg M</searchLink>; Cartilage Research Unit, Department of Orthopedics, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Barenius+B%22">Barenius B</searchLink>; Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sävendahl+L%22">Sävendahl L</searchLink>; Department of Women and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Adams+RH%22">Adams RH</searchLink>; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Gjertsson+I%22">Gjertsson I</searchLink>; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ohlsson+C%22">Ohlsson C</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Unit of Clinical Pharmacology, Department of Pharmaceuticals, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Volpe+G%22">Volpe G</searchLink>; Department of Physics, Gothenburg University, Gothenburg, Sweden.; Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Chagin+AS%22">Chagin AS</searchLink>; Centre for Bone and Arthritis Research, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. andrei.chagin@gu.se.; Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden. andrei.chagin@gu.se.
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