A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.

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Title: A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.
Authors: Sun S; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Zheng Y; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA., Kim YS; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Zhong Z; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Kobayashi N; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Xue X; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Division of Developmental Biology, Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Liu Y; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, USA., Zhou Z; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA., Xu Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Zhai J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Wang H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Fu J; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. jpfu@umich.edu.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA. jpfu@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. jpfu@umich.edu.
Source: Nature cell biology [Nat Cell Biol] 2026 May; Vol. 28 (5), pp. 1049-1065. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.
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  Data: <searchLink fieldCode="AU" term="%22Sun+S%22">Sun S</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+YS%22">Kim YS</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+Z%22">Zhong Z</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kobayashi+N%22">Kobayashi N</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Division of Developmental Biology, Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhai+J%22">Zhai J</searchLink>; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. jpfu@umich.edu.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA. jpfu@umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. jpfu@umich.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2026 May; Vol. 28 (5), pp. 1049-1065. <i>Date of Electronic Publication: </i>2026 Apr 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Macmillan+Magazines+Ltd%22">Macmillan Magazines Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100890575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4679 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214657392%22">14657392 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cell Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41556-026-01930-y
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              Text: 2026 May
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