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Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies.

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Title: Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies.
Authors: Kim S; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada., Lessard E; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Ling B; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Rennie K; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Haqqani A; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Maharaj AR; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada. anil.maharaj@ubc.ca.
Source: The AAPS journal [AAPS J] 2026 Apr 18; Vol. 28 (3). Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: <searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Lessard+E%22">Lessard E</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada.<br /><searchLink fieldCode="AU" term="%22Ling+B%22">Ling B</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada.<br /><searchLink fieldCode="AU" term="%22Rennie+K%22">Rennie K</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada.<br /><searchLink fieldCode="AU" term="%22Haqqani+A%22">Haqqani A</searchLink>; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada.<br /><searchLink fieldCode="AU" term="%22Maharaj+AR%22">Maharaj AR</searchLink>; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada. anil.maharaj@ubc.ca.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 Apr 18; Vol. 28 (3). <i>Date of Electronic Publication: </i>2026 Apr 18.
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        Value: 10.1208/s12248-026-01233-y
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        Text: English
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              Text: 2026 Apr 18
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