Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies.
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| Title: | Integrating In-vitro Permeability Assays within PBPK Modeling to Predict CNS Distribution of Standard and Engineered Antibodies. |
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| Authors: | Kim S; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada., Lessard E; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Ling B; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Rennie K; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Haqqani A; Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, K1A 0R6, Canada., Maharaj AR; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Bristish Columbia, V6T 1Z3, Canada. anil.maharaj@ubc.ca. |
| Source: | The AAPS journal [AAPS J] 2026 Apr 18; Vol. 28 (3). Date of Electronic Publication: 2026 Apr 18. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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