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Correlates of severe and delta COVID-19 in a phase 3 trial of the AZD1222 vaccine.

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Title: Correlates of severe and delta COVID-19 in a phase 3 trial of the AZD1222 vaccine.
Authors: Janes H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Fong Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Benkeser D; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Kelly EJ; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hirsch I; Biometrics, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Stanley AM; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Villafana T; Clinical Development, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Petropoulos CJ; LabCorp-Monogram Biosciences, South San Francisco, CA, USA., Leith A; Nexelis, Seattle, WA, USA., Haugaard D; Nexelis, Seattle, WA, USA., Webb B; Nexelis, Seattle, WA, USA., Lu Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Yu C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Borate B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., van der Laan LWP; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA., Hejazi NS; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Randhawa AK; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Andrasik MP; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kublin JG; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Isaacs MB; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA., Makhene M; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Tong T; Vaccine Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Robb ML; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Neuzil KM; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA., Follmann D; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Falsey AR; Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, NY, USA., Sobieszczyk ME; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, NY, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org.; Department of Biostatistics, University of Washington, Seattle, WA, USA. pgilbert@fredhutch.org.
Corporate Authors: AstraZeneca AZD1222 Clinical Study Group, Immune Assays Team, United States Government (USG)/CoVPN Biostatistics Team
Source: NPJ vaccines [NPJ Vaccines] 2026 Apr 18; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Correlates of severe and delta COVID-19 in a phase 3 trial of the AZD1222 vaccine.
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  Data: <searchLink fieldCode="AU" term="%22Janes+H%22">Janes H</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fong+Y%22">Fong Y</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Benkeser+D%22">Benkeser D</searchLink>; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+EJ%22">Kelly EJ</searchLink>; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hirsch+I%22">Hirsch I</searchLink>; Biometrics, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stanley+AM%22">Stanley AM</searchLink>; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Villafana+T%22">Villafana T</searchLink>; Clinical Development, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Petropoulos+CJ%22">Petropoulos CJ</searchLink>; LabCorp-Monogram Biosciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leith+A%22">Leith A</searchLink>; Nexelis, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Haugaard+D%22">Haugaard D</searchLink>; Nexelis, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Webb+B%22">Webb B</searchLink>; Nexelis, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Borate+B%22">Borate B</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22van+der+Laan+LWP%22">van der Laan LWP</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hejazi+NS%22">Hejazi NS</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Randhawa+AK%22">Randhawa AK</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Andrasik+MP%22">Andrasik MP</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kublin+JG%22">Kublin JG</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Isaacs+MB%22">Isaacs MB</searchLink>; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Makhene+M%22">Makhene M</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tong+T%22">Tong T</searchLink>; Vaccine Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Robb+ML%22">Robb ML</searchLink>; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Corey+L%22">Corey L</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Neuzil+KM%22">Neuzil KM</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Follmann+D%22">Follmann D</searchLink>; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Falsey+AR%22">Falsey AR</searchLink>; Division of Infectious Diseases, Department of Medicine, University of Rochester, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sobieszczyk+ME%22">Sobieszczyk ME</searchLink>; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+PB%22">Gilbert PB</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org.; Department of Biostatistics, University of Washington, Seattle, WA, USA. pgilbert@fredhutch.org.
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  Data: <searchLink fieldCode="CA" term="%22AstraZeneca+AZD1222+Clinical+Study+Group%22">AstraZeneca AZD1222 Clinical Study Group</searchLink><br /><searchLink fieldCode="CA" term="%22Immune+Assays+Team%22">Immune Assays Team</searchLink><br /><searchLink fieldCode="CA" term="%22United+States+Government+%28USG%29%2FCoVPN+Biostatistics+Team%22">United States Government (USG)/CoVPN Biostatistics Team</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101699863%22">NPJ vaccines</searchLink> [NPJ Vaccines] 2026 Apr 18; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Apr 18.
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