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Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.

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Title: Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.
Authors: Hu J; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Zheng C; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Feng Y; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Li Y; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Pei P; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Yang M; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Qu Y; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Zheng LT; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China., Zhang L; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. lizhang@suda.edu.cn., Zhen XC; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. zhenxuechu@suda.edu.cn., Wang Y; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. yuanw@suda.edu.cn.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (22), pp. 2085-2097. Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.
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  Data: <searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Pei+P%22">Pei P</searchLink>; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Qu+Y%22">Qu Y</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+LT%22">Zheng LT</searchLink>; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. lizhang@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhen+XC%22">Zhen XC</searchLink>; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. zhenxuechu@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Pediatric Cancer Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. yuanw@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jun; Vol. 45 (22), pp. 2085-2097. <i>Date of Electronic Publication: </i>2026 Apr 18.
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              Text: 2026 Jun
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