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Exosomal lncRNA SILC1 from bicalutamide-activated mesenchymal stem cells promotes prostate cancer survival and bicalutamide resistance via the miR-577/RHOA axis.

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Title: Exosomal lncRNA SILC1 from bicalutamide-activated mesenchymal stem cells promotes prostate cancer survival and bicalutamide resistance via the miR-577/RHOA axis.
Authors: Yu J; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Liang H; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Lu D; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Pham TH; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Mo Q; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Hussein MB; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Wen J; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.; Department of Urology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China., He Q; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Li Y; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Wei F; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Yang G; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.; Department of Urology, Affiliated Tumor Hospital of Guangxi Medical University, No. 71 Hedi Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Yan X; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Liao N; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Wei L; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China., Cui Z; Department of Urology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China., Chen H; Department of Urology, People's Hospital of Hunan Province, Changsha, Hunan, China., Qin M; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. 63086204@qq.com., Wang F; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. wangfubo@gxmu.edu.cn.; Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. wangfubo@gxmu.edu.cn., Cheng J; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. chengjiwen@stu.gxmu.edu.cn.; Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. chengjiwen@stu.gxmu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 Apr 18; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosomal lncRNA SILC1 from bicalutamide-activated mesenchymal stem cells promotes prostate cancer survival and bicalutamide resistance via the miR-577/RHOA axis.
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  Data: <searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lu+D%22">Lu D</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Pham+TH%22">Pham TH</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Mo+Q%22">Mo Q</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Hussein+MB%22">Hussein MB</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.; Department of Urology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wei+F%22">Wei F</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.; Department of Urology, Affiliated Tumor Hospital of Guangxi Medical University, No. 71 Hedi Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Liao+N%22">Liao N</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wei+L%22">Wei L</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China.<br /><searchLink fieldCode="AU" term="%22Cui+Z%22">Cui Z</searchLink>; Department of Urology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Urology, People's Hospital of Hunan Province, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Qin+M%22">Qin M</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. 63086204@qq.com.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. wangfubo@gxmu.edu.cn.; Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. wangfubo@gxmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cheng+J%22">Cheng J</searchLink>; Department of Urology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. chengjiwen@stu.gxmu.edu.cn.; Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, P. R. China. chengjiwen@stu.gxmu.edu.cn.
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        Value: 10.1186/s12967-026-08105-1
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      – TitleFull: Exosomal lncRNA SILC1 from bicalutamide-activated mesenchymal stem cells promotes prostate cancer survival and bicalutamide resistance via the miR-577/RHOA axis.
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              Text: 2026 Apr 18
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