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Developing blood extracellular vesicle protein biomarkers for hepatocellular carcinoma: mechanisms, methods, and translation.

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Title: Developing blood extracellular vesicle protein biomarkers for hepatocellular carcinoma: mechanisms, methods, and translation.
Authors: Zhuang Y; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.; West China School of Medicine, Sichuan University, Chengdu, 610041, China., Zeng W; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China., Long T; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China., Gao N; West China School of Medicine, Sichuan University, Chengdu, 610041, China., Zhong W; West China School of Medicine, Sichuan University, Chengdu, 610041, China., Mu H; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China., Wang X; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China., Yang H; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; West China School of Medicine, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; Protein Engineering and Proteomics Center, Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; No. 1, Keyuan 4th Road, Gaopeng Avenue, Hi-tech Zone, Chengdu, 610041, China. yanghao@scu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Apr 18; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 18.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Developing blood extracellular vesicle protein biomarkers for hepatocellular carcinoma: mechanisms, methods, and translation.
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  Data: <searchLink fieldCode="AU" term="%22Zhuang+Y%22">Zhuang Y</searchLink>; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.; West China School of Medicine, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Zeng+W%22">Zeng W</searchLink>; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Long+T%22">Long T</searchLink>; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Gao+N%22">Gao N</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Zhong+W%22">Zhong W</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Mu+H%22">Mu H</searchLink>; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Transplantation Center & Institute of Organ Transplantation, NHC Key Lab of Transplant Engineering and Immunology, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; West China School of Medicine, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; Proteomics and Metabolomics Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; Protein Engineering and Proteomics Center, Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application, West China Hospital, Sichuan University, Chengdu, 610041, China. yanghao@scu.edu.cn.; No. 1, Keyuan 4th Road, Gaopeng Avenue, Hi-tech Zone, Chengdu, 610041, China. yanghao@scu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Apr 18; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-026-04463-6
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              Text: 2026 Apr 18
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