Metabolic reprogramming of human macrophages drives the formation of hybrid M1/M2 pro-regenerative extracellular vesicles.

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Title: Metabolic reprogramming of human macrophages drives the formation of hybrid M1/M2 pro-regenerative extracellular vesicles.
Authors: Gorgun C; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy. Electronic address: cansu.gorgun@unige.it., Klavina P; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland., Martins CS; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland., Payet C; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland., Cavanagh BL; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland., Pultar M; TAmiRNA GmbH, Vienna, Austria., Hackl M; TAmiRNA GmbH, Vienna, Austria., Curtis AM; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Advanced Materials and Bioengineering Research Centre, Trinity College Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: anniecurtis@rcsi.ie., Hoey DA; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Advanced Materials and Bioengineering Research Centre, Trinity College Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: dahoey@tcd.ie.
Source: Biomaterials [Biomaterials] 2026 Oct; Vol. 333, pp. 124216. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
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  Data: Metabolic reprogramming of human macrophages drives the formation of hybrid M1/M2 pro-regenerative extracellular vesicles.
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  Data: <searchLink fieldCode="AU" term="%22Gorgun+C%22">Gorgun C</searchLink>; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy. Electronic address: cansu.gorgun@unige.it.<br /><searchLink fieldCode="AU" term="%22Klavina+P%22">Klavina P</searchLink>; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Martins+CS%22">Martins CS</searchLink>; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Payet+C%22">Payet C</searchLink>; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Cavanagh+BL%22">Cavanagh BL</searchLink>; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Pultar+M%22">Pultar M</searchLink>; TAmiRNA GmbH, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hackl+M%22">Hackl M</searchLink>; TAmiRNA GmbH, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Curtis+AM%22">Curtis AM</searchLink>; Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Advanced Materials and Bioengineering Research Centre, Trinity College Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: anniecurtis@rcsi.ie.<br /><searchLink fieldCode="AU" term="%22Hoey+DA%22">Hoey DA</searchLink>; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland; Department of Mechanical, Manufacturing, and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Advanced Materials and Bioengineering Research Centre, Trinity College Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: dahoey@tcd.ie.
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  Data: <searchLink fieldCode="JN" term="%228100316%22">Biomaterials</searchLink> [Biomaterials] 2026 Oct; Vol. 333, pp. 124216. <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8100316 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-5905 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201429612%22">01429612 </searchLink><i>NLM ISO Abbreviation: </i>Biomaterials <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biomaterials.2026.124216
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              Text: 2026 Oct
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