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Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.

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Title: Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.
Authors: Malamut G; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France., Guégan N; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France., Carbone F; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France., de Giacomoni A; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France., Ferment A; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France., Masson C; Imagine Institute, Bioinformatics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163, INSERM US24/CNRS UAR3633, Université Paris Cité, Paris, France., Luka M; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France., Cording S; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France., Bole C; Genomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163, INSERM US24/CNRS UAR3633, Université Paris Cité, Paris, France., Fumery M; Department of Hepato-Gastroenterology, CHU Amiens Picardie, France., Matysiak-Budnik T; Hépato-Gastroentérologie & Oncologie Digestive, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU de Nantes, France., Bouguen G; Department of Gastroenterology, Pontchaillou University Hospital, INSERM U991, CIC1414, Université de Rennes, France., Abitbol V; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France., Coriat R; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France., Terris B; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France., Burroni B; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France., Beuvon F; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France., Lhermitte L; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France., Brouzes C; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France., Duboc H; Department of Gastroenterology, AP-HP, Hôpital Louis Mourier, Université Paris Cité, Colombes, France., Nion-Larmurier I; Department of Gastroenterology, AP-HP, Hôpital Saint Antoine, Université Paris Sorbonne, Paris, France., Uzzan M; Department of Gastroenterology, AP-HP, Hôpitaux Universitaires Henri-Mondor, Université Paris Est Créteil, Créteil, France., Sibon D; Lymphoid Hematology Department, AP-HP, Hôpitaux Universitaires Henri-Mondor, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale INSERM U955, Créteil, France., Asnafi V; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France., Hermine O; Laboratory of Onco-Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France; Université Paris Cité, Imagine Institute, Laboratory of Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM UMR 1163, Paris, France., Ménager M; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France., Cerf-Bensussan N; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France. Electronic address: nadine.cerf-bensussan@inserm.fr., Levescot A; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France. Electronic address: anais.levescot@inserm.fr.
Source: Gastroenterology [Gastroenterology] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.
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  Data: <searchLink fieldCode="AU" term="%22Malamut+G%22">Malamut G</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Guégan+N%22">Guégan N</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Carbone+F%22">Carbone F</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22de+Giacomoni+A%22">de Giacomoni A</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ferment+A%22">Ferment A</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Masson+C%22">Masson C</searchLink>; Imagine Institute, Bioinformatics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163, INSERM US24/CNRS UAR3633, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Luka+M%22">Luka M</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cording+S%22">Cording S</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bole+C%22">Bole C</searchLink>; Genomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163, INSERM US24/CNRS UAR3633, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fumery+M%22">Fumery M</searchLink>; Department of Hepato-Gastroenterology, CHU Amiens Picardie, France.<br /><searchLink fieldCode="AU" term="%22Matysiak-Budnik+T%22">Matysiak-Budnik T</searchLink>; Hépato-Gastroentérologie & Oncologie Digestive, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU de Nantes, France.<br /><searchLink fieldCode="AU" term="%22Bouguen+G%22">Bouguen G</searchLink>; Department of Gastroenterology, Pontchaillou University Hospital, INSERM U991, CIC1414, Université de Rennes, France.<br /><searchLink fieldCode="AU" term="%22Abitbol+V%22">Abitbol V</searchLink>; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Coriat+R%22">Coriat R</searchLink>; Department of Gastroenterology, AP-HP, Centre-Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Terris+B%22">Terris B</searchLink>; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Burroni+B%22">Burroni B</searchLink>; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Beuvon+F%22">Beuvon F</searchLink>; Department of Pathology, AP-HP, Université Paris Cité, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lhermitte+L%22">Lhermitte L</searchLink>; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brouzes+C%22">Brouzes C</searchLink>; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Duboc+H%22">Duboc H</searchLink>; Department of Gastroenterology, AP-HP, Hôpital Louis Mourier, Université Paris Cité, Colombes, France.<br /><searchLink fieldCode="AU" term="%22Nion-Larmurier+I%22">Nion-Larmurier I</searchLink>; Department of Gastroenterology, AP-HP, Hôpital Saint Antoine, Université Paris Sorbonne, Paris, France.<br /><searchLink fieldCode="AU" term="%22Uzzan+M%22">Uzzan M</searchLink>; Department of Gastroenterology, AP-HP, Hôpitaux Universitaires Henri-Mondor, Université Paris Est Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Sibon+D%22">Sibon D</searchLink>; Lymphoid Hematology Department, AP-HP, Hôpitaux Universitaires Henri-Mondor, Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale INSERM U955, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Asnafi+V%22">Asnafi V</searchLink>; Université Paris Cité, Institut Necker-Enfants Malades, INSERM UMR 1151, Paris, France; Clinical Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hermine+O%22">Hermine O</searchLink>; Laboratory of Onco-Haematology, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Cité, Paris, France; Université Paris Cité, Imagine Institute, Laboratory of Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ménager+M%22">Ménager M</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Disease, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cerf-Bensussan+N%22">Cerf-Bensussan N</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France. Electronic address: nadine.cerf-bensussan@inserm.fr.<br /><searchLink fieldCode="AU" term="%22Levescot+A%22">Levescot A</searchLink>; Université Paris Cité, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France. Electronic address: anais.levescot@inserm.fr.
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