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The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes.

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Title: The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes.
Authors: Harrod A; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Feng H; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.; Present address: The Francis Crick Institute, London, UK., Ghaddar N; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Schiavoni F; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Lane KA; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Wu L; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Zuazua-Villar P; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Kozik Z; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Dobbs FM; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK., van Eijk P; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK., Koh GCC; Department of Genomic Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia., Somaiah N; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Choudhary J; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK., Nik-Zainal S; Department of Genomic Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Reed SH; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK., Downs JA; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK. Jessica.Downs@icr.ac.uk.
Source: Genome biology [Genome Biol] 2026 Apr 20; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Harrod+A%22">Harrod A</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Feng+H%22">Feng H</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.; Present address: The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Ghaddar+N%22">Ghaddar N</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Schiavoni+F%22">Schiavoni F</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Lane+KA%22">Lane KA</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Zuazua-Villar+P%22">Zuazua-Villar P</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Kozik+Z%22">Kozik Z</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Dobbs+FM%22">Dobbs FM</searchLink>; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22van+Eijk+P%22">van Eijk P</searchLink>; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Koh+GCC%22">Koh GCC</searchLink>; Department of Genomic Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.<br /><searchLink fieldCode="AU" term="%22Somaiah+N%22">Somaiah N</searchLink>; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Choudhary+J%22">Choudhary J</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Nik-Zainal+S%22">Nik-Zainal S</searchLink>; Department of Genomic Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Reed+SH%22">Reed SH</searchLink>; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.; Broken String Biosciences, BioData Innovation Centre, Wellcome Genome Campus, Unit AB303, Level 3, Cambridge, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Downs+JA%22">Downs JA</searchLink>; Division of Cell and Molecular Biology, The Institute of Cancer Research, London, UK. Jessica.Downs@icr.ac.uk.
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