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Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, in Vitro, and in Silico Evaluation.

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Title: Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, in Vitro, and in Silico Evaluation.
Authors: Pereira GRC; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Viana GM; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Huber MB; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Rodrigues PS; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Gonçalves ARSP; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Sathler PC; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Rodrigues CR; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Abrahim-Vieira BA; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Cabral LM; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.
Source: ACS omega [ACS Omega] 2026 Apr 01; Vol. 11 (14), pp. 21903-21925. Date of Electronic Publication: 2026 Apr 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Pereira+GRC%22">Pereira GRC</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Viana+GM%22">Viana GM</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Huber+MB%22">Huber MB</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+PS%22">Rodrigues PS</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+ARSP%22">Gonçalves ARSP</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Sathler+PC%22">Sathler PC</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+CR%22">Rodrigues CR</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Abrahim-Vieira+BA%22">Abrahim-Vieira BA</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Cabral+LM%22">Cabral LM</searchLink>; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil.
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              Text: 2026 Apr 01
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