Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, in Vitro, and in Silico Evaluation.
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| Title: | Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, in Vitro, and in Silico Evaluation. |
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| Authors: | Pereira GRC; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Viana GM; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Huber MB; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Rodrigues PS; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Gonçalves ARSP; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Sathler PC; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Rodrigues CR; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Abrahim-Vieira BA; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil., Cabral LM; †Laboratory of Molecular Modeling and QSAR; ‡Laboratory of Industrial Pharmaceutical Technology; §Laboratory of Experimental Hemostasis; Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, Rio de Janeiro, 21941-902, Brazil. |
| Source: | ACS omega [ACS Omega] 2026 Apr 01; Vol. 11 (14), pp. 21903-21925. Date of Electronic Publication: 2026 Apr 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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