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The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways.

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Title: The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways.
Authors: Bai XY; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Wang GL; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Zhang Y; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Cheng Q; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Feng HN; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Wei L; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Sheng HY; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Yin Y; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China., Roger S; INSERM U1327 ISCHEMIA 'Membrane Signalling and Inflammation in Reperfusion Injuries', Faculty of Medicine, University of Tours, Tours, France., Jiang LH; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.; INSERM U1327 ISCHEMIA 'Membrane Signalling and Inflammation in Reperfusion Injuries', Faculty of Medicine, University of Tours, Tours, France.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Hou H; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.
Source: Frontiers in immunology [Front Immunol] 2026 Apr 02; Vol. 17, pp. 1814913. Date of Electronic Publication: 2026 Apr 02 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways.
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  Data: <searchLink fieldCode="AU" term="%22Bai+XY%22">Bai XY</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+GL%22">Wang GL</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Cheng+Q%22">Cheng Q</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Feng+HN%22">Feng HN</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Wei+L%22">Wei L</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Sheng+HY%22">Sheng HY</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Yin+Y%22">Yin Y</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.<br /><searchLink fieldCode="AU" term="%22Roger+S%22">Roger S</searchLink>; INSERM U1327 ISCHEMIA 'Membrane Signalling and Inflammation in Reperfusion Injuries', Faculty of Medicine, University of Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Jiang+LH%22">Jiang LH</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.; INSERM U1327 ISCHEMIA 'Membrane Signalling and Inflammation in Reperfusion Injuries', Faculty of Medicine, University of Tours, Tours, France.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hou+H%22">Hou H</searchLink>; Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.; Henan Key Laboratory of Neurorestoratology and Protein Modification, Henan Medical University, Xinxiang, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Apr 02; Vol. 17, pp. 1814913. <i>Date of Electronic Publication: </i>2026 Apr 02 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1814913
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        Text: English
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      – TitleFull: The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways.
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              Text: 2026 Apr 02
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