Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma.

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Title: Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma.
Authors: Woo SM; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Kang JH; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; New Cancer Cure-Bio Co., Goyang, Republic of Korea., Choi W; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea., Lee H; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Jang H; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Sim SH; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea., Chun JW; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Koh EB; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kim C; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Ham W; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Hong W; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kang M; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Park J; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Han S; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kim JW; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea., Lee EW; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.; Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea., Lee WJ; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Kim SY; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.
Source: Cancer research [Cancer Res] 2026 Jul 02; Vol. 86 (13), pp. 3194-3212.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-25-4517