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Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma.

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Title: Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma.
Authors: Woo SM; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Kang JH; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; New Cancer Cure-Bio Co., Goyang, Republic of Korea., Choi W; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea., Lee H; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Jang H; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Sim SH; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea., Chun JW; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Koh EB; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kim C; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Ham W; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Hong W; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kang M; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Park J; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Han S; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea., Kim JW; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea., Lee EW; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.; Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea., Lee WJ; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea., Kim SY; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.
Source: Cancer research [Cancer Res] 2026 Jul 02; Vol. 86 (13), pp. 3194-3212.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Woo+SM%22">Woo SM</searchLink>; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+JH%22">Kang JH</searchLink>; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; New Cancer Cure-Bio Co., Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+W%22">Choi W</searchLink>; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+H%22">Jang H</searchLink>; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sim+SH%22">Sim SH</searchLink>; Therapeutic Resistance Research Branch, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chun+JW%22">Chun JW</searchLink>; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Koh+EB%22">Koh EB</searchLink>; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+C%22">Kim C</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ham+W%22">Ham W</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+W%22">Hong W</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JW%22">Kim JW</searchLink>; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EW%22">Lee EW</searchLink>; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.; Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea.; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+WJ%22">Lee WJ</searchLink>; Research Institute, National Cancer Center, Goyang, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; New Cancer Cure-Bio Co., Goyang, Republic of Korea.; Cancer Molecular Biology Branch, Research Institute of National Cancer Center, Goyang, Republic of Korea.
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        Value: 10.1158/0008-5472.CAN-25-4517
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        Text: English
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              Text: 2026 Jul 02
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