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First-in-Human, Phase I Study of Sigvotatug Vedotin, an Integrin Beta-6-Directed Antibody-Drug Conjugate: Results From Dose Expansion in Advanced Non-Small Cell Lung Cancer.

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Title: First-in-Human, Phase I Study of Sigvotatug Vedotin, an Integrin Beta-6-Directed Antibody-Drug Conjugate: Results From Dose Expansion in Advanced Non-Small Cell Lung Cancer.
Authors: Peters S; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Piha-Paul SA; The University of Texas MD Anderson Cancer Center, Houston, TX., Sehgal K; Dana-Farber Cancer Institute, Boston, MA., Calvo E; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain., Bockorny B; Beth Israel Deaconess Medical Center, Boston, MA., Galvao V; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Dowlati A; University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, OH., Fontana E; Sarah Cannon Research Institute UK, London, United Kingdom., Hernandez-Guerrero T; START Barcelona-HM Nou Delfos, Barcelona, Spain., Rivera Herrero F; Oncology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain., Kingsley E; Comprehensive Cancer Centers of Nevada, Las Vegas, NV., Lopez JS; Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London, United Kingdom., Patnaik A; The START Center for Cancer Research, San Antonio, TX., Perez CA; Sarah Cannon Research Institute at Florida Cancer Specialists-Lake Nona, Orlando, FL., Sanborn RE; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR., Knowles S; Pfizer, Bothell, WA., Patilea-Vrana G; Pfizer, Bothell, WA., Li J; Pfizer, La Jolla, CA., Wang T; Pfizer, South San Francisco, CA., Wang Y; Pfizer, Bothell, WA., Hollebecque A; Institut Gustave Roussy, Villejuif, France.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1635-1645. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-Human, Phase I Study of Sigvotatug Vedotin, an Integrin Beta-6-Directed Antibody-Drug Conjugate: Results From Dose Expansion in Advanced Non-Small Cell Lung Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Peters+S%22">Peters S</searchLink>; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Piha-Paul+SA%22">Piha-Paul SA</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Sehgal+K%22">Sehgal K</searchLink>; Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Calvo+E%22">Calvo E</searchLink>; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bockorny+B%22">Bockorny B</searchLink>; Beth Israel Deaconess Medical Center, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Galvao+V%22">Galvao V</searchLink>; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dowlati+A%22">Dowlati A</searchLink>; University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, OH.<br /><searchLink fieldCode="AU" term="%22Fontana+E%22">Fontana E</searchLink>; Sarah Cannon Research Institute UK, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hernandez-Guerrero+T%22">Hernandez-Guerrero T</searchLink>; START Barcelona-HM Nou Delfos, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rivera+Herrero+F%22">Rivera Herrero F</searchLink>; Oncology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Kingsley+E%22">Kingsley E</searchLink>; Comprehensive Cancer Centers of Nevada, Las Vegas, NV.<br /><searchLink fieldCode="AU" term="%22Lopez+JS%22">Lopez JS</searchLink>; Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patnaik+A%22">Patnaik A</searchLink>; The START Center for Cancer Research, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Perez+CA%22">Perez CA</searchLink>; Sarah Cannon Research Institute at Florida Cancer Specialists-Lake Nona, Orlando, FL.<br /><searchLink fieldCode="AU" term="%22Sanborn+RE%22">Sanborn RE</searchLink>; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Knowles+S%22">Knowles S</searchLink>; Pfizer, Bothell, WA.<br /><searchLink fieldCode="AU" term="%22Patilea-Vrana+G%22">Patilea-Vrana G</searchLink>; Pfizer, Bothell, WA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Pfizer, La Jolla, CA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Pfizer, South San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Pfizer, Bothell, WA.<br /><searchLink fieldCode="AU" term="%22Hollebecque+A%22">Hollebecque A</searchLink>; Institut Gustave Roussy, Villejuif, France.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1635-1645. <i>Date of Electronic Publication: </i>2026 Apr 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE
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