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LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.

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Title: LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.
Authors: Pillai R; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York.; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, New York., Rashidfarrokhi A; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York., Hao Y; Applied Bioinformatics Laboratories, New York University Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Wu WL; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York., Mancini MCS; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil., Karadal-Ferrena B; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Department of Basic Oncology, Hacettepe University, Ankara, Turkey., Dimitriadoy SG; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Cross M; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York., Yeaton AH; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Huang SM; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Bhutkar A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Herrera AM; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, New York., Rajalingam S; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Hayashi M; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Huang KL; Department of Genetics and Genomic Sciences, Center for Transformative Disease Modeling, Tisch Cancer Institute, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York., Bartnicki E; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York.; Department of Microbiology, New York University Langone Health, New York, New York., Zavitsanou AM; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York., Ivanova E; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Wohlhieter C; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., LeBoeuf SE; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Chen T; Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York., Loomis CA; Experimental Pathology Research Laboratory (RRID:SCR_017928), New York University Langone Health, New York, New York., Kulicke R; Celsius Therapeutics, Cambridge, Massachusetts., Davis FP; Celsius Therapeutics, Cambridge, Massachusetts., Stransky N; Celsius Therapeutics, Cambridge, Massachusetts., Smolen GA; Celsius Therapeutics, Cambridge, Massachusetts., Tsay JJ; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, New York., Simabuco FM; Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Rudin CM; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Moreira AL; Department of Pathology, New York University Grossman School of Medicine, New York, New York., Khanna KM; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Microbiology, New York University Langone Health, New York, New York., Pass HI; Department of Cardiothoracic Surgery, New York University Langone Health, New York, New York., Wong KK; Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York., Koide S; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Biochemistry & Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York., Tsirigos A; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Applied Bioinformatics Laboratories, New York University Langone Health, New York, New York., Koralov SB; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Papagiannakopoulos T; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.
Source: Cancer discovery [Cancer Discov] 2026 Jul 01; Vol. 16 (7), pp. 1436-1455.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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  Data: LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.
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Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mancini+MCS%22">Mancini MCS</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Karadal-Ferrena+B%22">Karadal-Ferrena B</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Department of Basic Oncology, Hacettepe University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Dimitriadoy+SG%22">Dimitriadoy SG</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Cross+M%22">Cross M</searchLink>; 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Celsius Therapeutics, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Davis+FP%22">Davis FP</searchLink>; Celsius Therapeutics, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stransky+N%22">Stransky N</searchLink>; Celsius Therapeutics, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Smolen+GA%22">Smolen GA</searchLink>; Celsius Therapeutics, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Tsay+JJ%22">Tsay JJ</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, New York.<br /><searchLink fieldCode="AU" term="%22Simabuco+FM%22">Simabuco FM</searchLink>; Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rudin+CM%22">Rudin CM</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Moreira+AL%22">Moreira AL</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Khanna+KM%22">Khanna KM</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Microbiology, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pass+HI%22">Pass HI</searchLink>; Department of Cardiothoracic Surgery, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wong+KK%22">Wong KK</searchLink>; Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Koide+S%22">Koide S</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Biochemistry & Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22Tsirigos+A%22">Tsirigos A</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Applied Bioinformatics Laboratories, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Koralov+SB%22">Koralov SB</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Papagiannakopoulos+T%22">Papagiannakopoulos T</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.
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