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Hospital in-use evaluation of the physical, chemical and affinity stability of the antibody-drug conjugate trastuzumab deruxtecan (Enhertu®).

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Title: Hospital in-use evaluation of the physical, chemical and affinity stability of the antibody-drug conjugate trastuzumab deruxtecan (Enhertu®).
Authors: Douez E; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France; Pharmacy Department, Tours University Hospital, F-37200, France. Electronic address: emmanuel.douez@univ-tours.fr., Joubert N; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France., Gabant G; UPR 4301 CBM, CNRS, MO2VING platform, University of Orleans, 45100 Tours, France., Vidy E; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France., Auvert E; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France., Boursin F; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France., Dupeyrol G; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France., André V; Pharmacy Department, Tours University Hospital, F-37200, France., Velge Roussel F; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France., Denevault-Sabourin C; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France., Aubrey N; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France., Allard-Vannier E; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2026 Jun 01; Vol. 221, pp. 107536. Date of Electronic Publication: 2026 Apr 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hospital in-use evaluation of the physical, chemical and affinity stability of the antibody-drug conjugate trastuzumab deruxtecan (Enhertu®).
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  Data: <searchLink fieldCode="AU" term="%22Douez+E%22">Douez E</searchLink>; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France; Pharmacy Department, Tours University Hospital, F-37200, France. Electronic address: emmanuel.douez@univ-tours.fr.<br /><searchLink fieldCode="AU" term="%22Joubert+N%22">Joubert N</searchLink>; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France.<br /><searchLink fieldCode="AU" term="%22Gabant+G%22">Gabant G</searchLink>; UPR 4301 CBM, CNRS, MO2VING platform, University of Orleans, 45100 Tours, France.<br /><searchLink fieldCode="AU" term="%22Vidy+E%22">Vidy E</searchLink>; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France.<br /><searchLink fieldCode="AU" term="%22Auvert+E%22">Auvert E</searchLink>; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France.<br /><searchLink fieldCode="AU" term="%22Boursin+F%22">Boursin F</searchLink>; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France.<br /><searchLink fieldCode="AU" term="%22Dupeyrol+G%22">Dupeyrol G</searchLink>; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France.<br /><searchLink fieldCode="AU" term="%22André+V%22">André V</searchLink>; Pharmacy Department, Tours University Hospital, F-37200, France.<br /><searchLink fieldCode="AU" term="%22Velge+Roussel+F%22">Velge Roussel F</searchLink>; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France.<br /><searchLink fieldCode="AU" term="%22Denevault-Sabourin+C%22">Denevault-Sabourin C</searchLink>; UMR 1100, CEPR, Team Proteolytic enzymes and their pharmacological targeting in lung diseases, University of Tours, INSERM, F-37032 Tours, France.<br /><searchLink fieldCode="AU" term="%22Aubrey+N%22">Aubrey N</searchLink>; UMR 1282 ISP, Team BioMAP, University of Tours - INRAE, F-37200 Tours, France.<br /><searchLink fieldCode="AU" term="%22Allard-Vannier+E%22">Allard-Vannier E</searchLink>; UPR 4301 CBM, CNRS, NMNS department, University of Tours, F-37200 Tours, France.
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  Data: <searchLink fieldCode="JN" term="%229317982%22">European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences</searchLink> [Eur J Pharm Sci] 2026 Jun 01; Vol. 221, pp. 107536. <i>Date of Electronic Publication: </i>2026 Apr 19.
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