Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2.

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Title: Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2.
Authors: Nguyen YTK; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Chen F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Giang E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Saha S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Ueno LA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Chen C; Southwest National Primate Research Centre (SNPRC) at Texas Biomedical Research Institute, San Antonio, TX, USA.; PKD Foundation, Kansas City, MO, USA., Watson CT; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Tzarum N; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Faculty of Mathematics & Science, The Hebrew University of Jerusalem, Jerusalem, Israel., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu., Law M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. mlaw@scripps.edu., Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. robyn@scripps.edu.
Source: NPJ vaccines [NPJ Vaccines] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines
Database: MEDLINE Ultimate
Description
ISSN:2059-0105
DOI:10.1038/s41541-026-01449-1