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Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.

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Title: Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.
Authors: Celay J; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Recalde M; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Revuelta MV; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA., Larrayoz M; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Vicente C; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Lozano T; Program of Immunology and Immunotherapy, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona, Spain., Gil C; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Chapman JR; Department of Pathology and Laboratory Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Garcia-Lacarte M; Department of Biochemistry and Genetics, Universidad de Navarra, IDISNA, CIBERONC, Pamplona, Spain., Gonzalez C; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Ariceta B; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Rodriguez S; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Lasa M; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Garcia-Barchino MJ; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Fresquet V; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Jimenez M; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Sanz S; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Du MQ; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Roncador G; Monoclonal Antibodies Unit, Spanish National Cancer Research Center CNIO, Biotechnology Program, Madrid, Spain., Vega Z; Histopathology Unit, Spanish National Cancer Research Center CNIO, Biotechnology Program, Madrid, Spain., Sacco A; Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civil Di Brescia, Brescia, Italy., Roccaro A; Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civil Di Brescia, Brescia, Italy., Knittel G; Department of Hematology and Stem Cell Transplantation, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany., Piazza R; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Herter S; Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland., Goodhew R; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Caron J; Centre de Recherche Des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France., Roos-Weil D; Centre de Recherche Des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France., Miguel JS; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Canales M; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Hodson DJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Lossos IS; Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Lasarte JJ; Program of Immunology and Immunotherapy, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona, Spain., Roa S; Department of Biochemistry and Genetics, Universidad de Navarra, IDISNA, CIBERONC, Pamplona, Spain., Prosper F; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Paiva B; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain., Cerchietti L; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA. lec2010@med.cornell.edu.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, 1300 York Ave., Meyer Research Building C-640, New York, NY, 10065, USA. lec2010@med.cornell.edu., Martinez-Climent JA; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain. jamcliment@unav.es.; Division of Hemato-Oncology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Avda. Pio XII, 55; 31008, Pamplona, Spain. jamcliment@unav.es.
Source: Molecular cancer [Mol Cancer] 2026 Apr 20. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas.
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  Data: <searchLink fieldCode="AU" term="%22Celay+J%22">Celay J</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Recalde+M%22">Recalde M</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Revuelta+MV%22">Revuelta MV</searchLink>; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Larrayoz+M%22">Larrayoz M</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Vicente+C%22">Vicente C</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lozano+T%22">Lozano T</searchLink>; Program of Immunology and Immunotherapy, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Gil+C%22">Gil C</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Chapman+JR%22">Chapman JR</searchLink>; Department of Pathology and Laboratory Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Lacarte+M%22">Garcia-Lacarte M</searchLink>; Department of Biochemistry and Genetics, Universidad de Navarra, IDISNA, CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez+C%22">Gonzalez C</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Ariceta+B%22">Ariceta B</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez+S%22">Rodriguez S</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lasa+M%22">Lasa M</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Barchino+MJ%22">Garcia-Barchino MJ</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Fresquet+V%22">Fresquet V</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Jimenez+M%22">Jimenez M</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+S%22">Sanz S</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Du+MQ%22">Du MQ</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Roncador+G%22">Roncador G</searchLink>; Monoclonal Antibodies Unit, Spanish National Cancer Research Center CNIO, Biotechnology Program, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vega+Z%22">Vega Z</searchLink>; Histopathology Unit, Spanish National Cancer Research Center CNIO, Biotechnology Program, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sacco+A%22">Sacco A</searchLink>; Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civil Di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Roccaro+A%22">Roccaro A</searchLink>; Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civil Di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Knittel+G%22">Knittel G</searchLink>; Department of Hematology and Stem Cell Transplantation, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+HC%22">Reinhardt HC</searchLink>; Department of Hematology and Stem Cell Transplantation, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Piazza+R%22">Piazza R</searchLink>; Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Herter+S%22">Herter S</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goodhew+R%22">Goodhew R</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Caron+J%22">Caron J</searchLink>; Centre de Recherche Des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France.<br /><searchLink fieldCode="AU" term="%22Roos-Weil+D%22">Roos-Weil D</searchLink>; Centre de Recherche Des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, Paris, France.<br /><searchLink fieldCode="AU" term="%22Miguel+JS%22">Miguel JS</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Canales+M%22">Canales M</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Hodson+DJ%22">Hodson DJ</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lossos+IS%22">Lossos IS</searchLink>; Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lasarte+JJ%22">Lasarte JJ</searchLink>; Program of Immunology and Immunotherapy, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Roa+S%22">Roa S</searchLink>; Department of Biochemistry and Genetics, Universidad de Navarra, IDISNA, CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Prosper+F%22">Prosper F</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Cerchietti+L%22">Cerchietti L</searchLink>; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA. lec2010@med.cornell.edu.; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, 1300 York Ave., Meyer Research Building C-640, New York, NY, 10065, USA. lec2010@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Martinez-Climent+JA%22">Martinez-Climent JA</searchLink>; Department of Hematology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Navarra Institute for Health Research (IDISNA), CIBERONC, Pamplona, Spain. jamcliment@unav.es.; Division of Hemato-Oncology, Center for Applied Medical Research, Cancer Center Clinica Univeridad de Navarra, University of Navarra, Avda. Pio XII, 55; 31008, Pamplona, Spain. jamcliment@unav.es.
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