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Diagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis.

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Title: Diagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis.
Authors: Toljan K; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA., Renner B; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Daboul L; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Martin ML; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cao Q; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., O'Donnell CM; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rodrigues P; QMENTA Inc., Boston, MA, USA., Derbyshire J; Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Azevedo CJ; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Bar-Or A; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Caverzasi E; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy., Calabresi PA; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Cree BAC; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA., Freeman L; Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Henry RG; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA., Longbrake EE; Department of Neurology, Yale University, New Haven, CT, USA., Nakamura K; Department of Biomedical Engineering, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH, USA., Oh J; Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada., Papinutto N; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA., Pelletier D; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Samudralwar RD; Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA., Schindler MK; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sotirchos ES; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Sicotte NL; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Solomon AJ; Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Shinohara RT; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sati P; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ontaneda D; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2026 May; Vol. 32 (6), pp. 614-623. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Toljan+K%22">Toljan K</searchLink>; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Renner+B%22">Renner B</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Daboul+L%22">Daboul L</searchLink>; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ML%22">Martin ML</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Q%22">Cao Q</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Donnell+CM%22">O'Donnell CM</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+P%22">Rodrigues P</searchLink>; QMENTA Inc., Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Derbyshire+J%22">Derbyshire J</searchLink>; Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Azevedo+CJ%22">Azevedo CJ</searchLink>; Department of Neurology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Or+A%22">Bar-Or A</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Caverzasi+E%22">Caverzasi E</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Calabresi+PA%22">Calabresi PA</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cree+BAC%22">Cree BAC</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+L%22">Freeman L</searchLink>; Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Henry+RG%22">Henry RG</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Longbrake+EE%22">Longbrake EE</searchLink>; Department of Neurology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nakamura+K%22">Nakamura K</searchLink>; Department of Biomedical Engineering, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Papinutto+N%22">Papinutto N</searchLink>; Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pelletier+D%22">Pelletier D</searchLink>; Department of Neurology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Samudralwar+RD%22">Samudralwar RD</searchLink>; Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+MK%22">Schindler MK</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sotirchos+ES%22">Sotirchos ES</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sicotte+NL%22">Sicotte NL</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Solomon+AJ%22">Solomon AJ</searchLink>; Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA.<br /><searchLink fieldCode="AU" term="%22Shinohara+RT%22">Shinohara RT</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Endeavor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Reich+DS%22">Reich DS</searchLink>; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sati+P%22">Sati P</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ontaneda+D%22">Ontaneda D</searchLink>; Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
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  Data: <searchLink fieldCode="JN" term="%229509185%22">Multiple sclerosis (Houndmills, Basingstoke, England)</searchLink> [Mult Scler] 2026 May; Vol. 32 (6), pp. 614-623. <i>Date of Electronic Publication: </i>2026 Apr 20.
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              Text: 2026 May
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