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CD28-driven ex vivo generation of stem-like memory CD8+ T cells bypassing CD3/TCR signaling.

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Title: CD28-driven ex vivo generation of stem-like memory CD8+ T cells bypassing CD3/TCR signaling.
Authors: Ihara F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Ohashi Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Zheng EYF; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Fukao S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Rodrigo R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Noamani B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Boukhaled GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Wang BX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Han DH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Wei X; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Burt BD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Saso K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Matsunaga Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Ly D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Kagoya Y; Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University, Tokyo 160-8582, Japan., Butler MO; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Mak TW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Saibil SD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Hirano N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2524626123. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: CD28-driven ex vivo generation of stem-like memory CD8<superscript>+</superscript> T cells bypassing CD3/TCR signaling.
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  Data: <searchLink fieldCode="AU" term="%22Ihara+F%22">Ihara F</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Ohashi+Y%22">Ohashi Y</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Zheng+EYF%22">Zheng EYF</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Fukao+S%22">Fukao S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Rodrigo+R%22">Rodrigo R</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Noamani+B%22">Noamani B</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Boukhaled+GM%22">Boukhaled GM</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+BX%22">Wang BX</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Han+DH%22">Han DH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Burt+BD%22">Burt BD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Saso+K%22">Saso K</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Matsunaga+Y%22">Matsunaga Y</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Ly+D%22">Ly D</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Kagoya+Y%22">Kagoya Y</searchLink>; Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University, Tokyo 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Butler+MO%22">Butler MO</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Mak+TW%22">Mak TW</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Saibil+SD%22">Saibil SD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Hirano+N%22">Hirano N</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2524626123. <i>Date of Electronic Publication: </i>2026 Apr 21.
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