CD28-driven ex vivo generation of stem-like memory CD8+ T cells bypassing CD3/TCR signaling.
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| Title: | CD28-driven ex vivo generation of stem-like memory CD8+ T cells bypassing CD3/TCR signaling. |
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| Authors: | Ihara F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Ohashi Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Zheng EYF; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Fukao S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Rodrigo R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Noamani B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Boukhaled GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Wang BX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Han DH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Wei X; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Burt BD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Saso K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Matsunaga Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Ly D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada., Kagoya Y; Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University, Tokyo 160-8582, Japan., Butler MO; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Mak TW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Saibil SD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Hirano N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 28; Vol. 123 (17), pp. e2524626123. Date of Electronic Publication: 2026 Apr 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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