C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC.

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Title: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC.
Authors: Khan IN; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ishratnourin-khan@uiowa.edu., Awasthi K; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: Krishna-awasthi@uiowa.edu., Wang Z; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ziyu-wang-1@uiowa.edu., Irfan NM; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nafis-mdirfan@uiowa.edu., Saepoo J; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: jirayu-saepoo@uiowa.edu., Whittier JN; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: joan-whittier@uiowa.edu., Koyuncu N; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nurgul-koyunce@uiowa.edu., Mogal MR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mdroman-mogal@uiowa.edu., Hasibuzzaman MM; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mm-hasibuzzaman@uiowa.edu., Yang S; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: shujie-yang@uiowa.edu., Petronek M; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: michael-petronek@uiowa.edu., Simons AL; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: andrean-simons@uiowa.edu.
Source: Redox biology [Redox Biol] 2026 Jun; Vol. 93, pp. 104172. Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC.
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  Data: <searchLink fieldCode="AU" term="%22Khan+IN%22">Khan IN</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ishratnourin-khan@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Awasthi+K%22">Awasthi K</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: Krishna-awasthi@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ziyu-wang-1@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Irfan+NM%22">Irfan NM</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nafis-mdirfan@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Saepoo+J%22">Saepoo J</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: jirayu-saepoo@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Whittier+JN%22">Whittier JN</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: joan-whittier@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Koyuncu+N%22">Koyuncu N</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nurgul-koyunce@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Mogal+MR%22">Mogal MR</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mdroman-mogal@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Hasibuzzaman+MM%22">Hasibuzzaman MM</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mm-hasibuzzaman@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: shujie-yang@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Petronek+M%22">Petronek M</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: michael-petronek@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Simons+AL%22">Simons AL</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: andrean-simons@uiowa.edu.
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