C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC.
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| Title: | C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC. |
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| Authors: | Khan IN; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ishratnourin-khan@uiowa.edu., Awasthi K; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: Krishna-awasthi@uiowa.edu., Wang Z; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ziyu-wang-1@uiowa.edu., Irfan NM; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nafis-mdirfan@uiowa.edu., Saepoo J; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: jirayu-saepoo@uiowa.edu., Whittier JN; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: joan-whittier@uiowa.edu., Koyuncu N; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nurgul-koyunce@uiowa.edu., Mogal MR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mdroman-mogal@uiowa.edu., Hasibuzzaman MM; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mm-hasibuzzaman@uiowa.edu., Yang S; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: shujie-yang@uiowa.edu., Petronek M; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: michael-petronek@uiowa.edu., Simons AL; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: andrean-simons@uiowa.edu. |
| Source: | Redox biology [Redox Biol] 2026 Jun; Vol. 93, pp. 104172. Date of Electronic Publication: 2026 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42013543 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Khan+IN%22">Khan IN</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ishratnourin-khan@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Awasthi+K%22">Awasthi K</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: Krishna-awasthi@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: ziyu-wang-1@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Irfan+NM%22">Irfan NM</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nafis-mdirfan@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Saepoo+J%22">Saepoo J</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: jirayu-saepoo@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Whittier+JN%22">Whittier JN</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: joan-whittier@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Koyuncu+N%22">Koyuncu N</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: nurgul-koyunce@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Mogal+MR%22">Mogal MR</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mdroman-mogal@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Hasibuzzaman+MM%22">Hasibuzzaman MM</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: mm-hasibuzzaman@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: shujie-yang@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Petronek+M%22">Petronek M</searchLink>; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: michael-petronek@uiowa.edu.<br /><searchLink fieldCode="AU" term="%22Simons+AL%22">Simons AL</searchLink>; Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, USA; Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: andrean-simons@uiowa.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 Jun; Vol. 93, pp. 104172. <i>Date of Electronic Publication: </i>2026 Apr 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42013543 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.redox.2026.104172 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 104172 Titles: – TitleFull: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Khan IN – PersonEntity: Name: NameFull: Awasthi K – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Irfan NM – PersonEntity: Name: NameFull: Saepoo J – PersonEntity: Name: NameFull: Whittier JN – PersonEntity: Name: NameFull: Koyuncu N – PersonEntity: Name: NameFull: Mogal MR – PersonEntity: Name: NameFull: Hasibuzzaman MM – PersonEntity: Name: NameFull: Yang S – PersonEntity: Name: NameFull: Petronek M – PersonEntity: Name: NameFull: Simons AL IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2213-2317 Numbering: – Type: volume Value: 93 Titles: – TitleFull: Redox biology Type: main |
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