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Using effect biomarker thresholds in regulatory risk assessment: an OECD-based framework for assessing cumulative exposures to chemical mixtures.

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Title: Using effect biomarker thresholds in regulatory risk assessment: an OECD-based framework for assessing cumulative exposures to chemical mixtures.
Authors: Hernández AF; Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain; Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain., Jeddi MZ; Shell Global Solutions International BV, The Hague, the Netherlands., Wilks MF; University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland., FitzGerald R; University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland., Duca RC; Health Directorate, Department Health Protection, Luxembourg., Villeneuve D; United States of America Environmental Protection Agency (US-EPA), United States of America., Viegas S; NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal., Hotta A; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France., Baucher MA; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France., Browne P; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France., Scholten B; Netherlands Organisation for Applied Scientific Research (TNO), the Netherlands., Simon E; Federal Office for the Environment (FOEN), Monbijoustrasse 40, 3011 Bern, Switzerland., Poddalgoda D; Existing Substances Risk Assessment Bureau, Health Canada, Canada., Bal-Price A; European Commission, Joint Research Centre (JRC), Ispra, Italy., Mustieles V; Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain; Servicio de Radiodiagnóstico, Hospital Universitario Clínico San Cecilio, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., van Thriel C; Leibniz Institut für Arbeitsforschung an der TU Dortmund (IFADO), Germany., Bonassi S; San Raffaele University, Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele, Roma, Italy., Fenech M; University of South Australia, Australia., Ndaw S; French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, Vandoeuvre les Nancy, France., Pieper C; German Federal Institute for Risk Assessment (BFR), Max-Dohrn-Str. 8-10, 10589 Berlin, Germany., Rissler J; Institut für Arbeitsschutz der DGUV (IFA) Division Exposure and Risk Assessment, Statistics, Alte Heerstr. 111, 53757 Sankt Augustin, Germany., Paini A; European Food Safety Authority (EFSA), Via Carlo Magno 1A, 43126 Parma, Italy., Farcal L; European Food Safety Authority (EFSA), Via Carlo Magno 1A, 43126 Parma, Italy., Schmid K; State Secretariat for Economic Affairs (SECO), Section Chemicals and Occupational Health, Holzikofenweg 36, 3003 Bern, Switzerland., Pasanen-Kase R; State Secretariat for Economic Affairs (SECO), Section Chemicals and Occupational Health, Holzikofenweg 36, 3003 Bern, Switzerland. Electronic address: robert.pasanen-kase@seco.admin.ch., Hopf NB; Unisanté, University Center for Primary Care and Public Health & University of Lausanne, Route de la Corniche 21, 1010 Lausanne, Switzerland. Electronic address: nancy.hopf@unisante.ch.
Source: Environment international [Environ Int] 2026 May; Vol. 211, pp. 110215. Date of Electronic Publication: 2026 Apr 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
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  Data: Using effect biomarker thresholds in regulatory risk assessment: an OECD-based framework for assessing cumulative exposures to chemical mixtures.
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  Data: <searchLink fieldCode="AU" term="%22Hernández+AF%22">Hernández AF</searchLink>; Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain; Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jeddi+MZ%22">Jeddi MZ</searchLink>; Shell Global Solutions International BV, The Hague, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wilks+MF%22">Wilks MF</searchLink>; University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22FitzGerald+R%22">FitzGerald R</searchLink>; University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Duca+RC%22">Duca RC</searchLink>; Health Directorate, Department Health Protection, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Villeneuve+D%22">Villeneuve D</searchLink>; United States of America Environmental Protection Agency (US-EPA), United States of America.<br /><searchLink fieldCode="AU" term="%22Viegas+S%22">Viegas S</searchLink>; NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Hotta+A%22">Hotta A</searchLink>; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France.<br /><searchLink fieldCode="AU" term="%22Baucher+MA%22">Baucher MA</searchLink>; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France.<br /><searchLink fieldCode="AU" term="%22Browne+P%22">Browne P</searchLink>; OECD, Rue André Pascal 2, 75775 Paris Cedex 16, France.<br /><searchLink fieldCode="AU" term="%22Scholten+B%22">Scholten B</searchLink>; Netherlands Organisation for Applied Scientific Research (TNO), the Netherlands.<br /><searchLink fieldCode="AU" term="%22Simon+E%22">Simon E</searchLink>; Federal Office for the Environment (FOEN), Monbijoustrasse 40, 3011 Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Poddalgoda+D%22">Poddalgoda D</searchLink>; Existing Substances Risk Assessment Bureau, Health Canada, Canada.<br /><searchLink fieldCode="AU" term="%22Bal-Price+A%22">Bal-Price A</searchLink>; European Commission, Joint Research Centre (JRC), Ispra, Italy.<br /><searchLink fieldCode="AU" term="%22Mustieles+V%22">Mustieles V</searchLink>; Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain; Servicio de Radiodiagnóstico, Hospital Universitario Clínico San Cecilio, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+Thriel+C%22">van Thriel C</searchLink>; Leibniz Institut für Arbeitsforschung an der TU Dortmund (IFADO), Germany.<br /><searchLink fieldCode="AU" term="%22Bonassi+S%22">Bonassi S</searchLink>; San Raffaele University, Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Fenech+M%22">Fenech M</searchLink>; University of South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Ndaw+S%22">Ndaw S</searchLink>; French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, Vandoeuvre les Nancy, France.<br /><searchLink fieldCode="AU" term="%22Pieper+C%22">Pieper C</searchLink>; German Federal Institute for Risk Assessment (BFR), Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rissler+J%22">Rissler J</searchLink>; Institut für Arbeitsschutz der DGUV (IFA) Division Exposure and Risk Assessment, Statistics, Alte Heerstr. 111, 53757 Sankt Augustin, Germany.<br /><searchLink fieldCode="AU" term="%22Paini+A%22">Paini A</searchLink>; European Food Safety Authority (EFSA), Via Carlo Magno 1A, 43126 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Farcal+L%22">Farcal L</searchLink>; European Food Safety Authority (EFSA), Via Carlo Magno 1A, 43126 Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Schmid+K%22">Schmid K</searchLink>; State Secretariat for Economic Affairs (SECO), Section Chemicals and Occupational Health, Holzikofenweg 36, 3003 Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pasanen-Kase+R%22">Pasanen-Kase R</searchLink>; State Secretariat for Economic Affairs (SECO), Section Chemicals and Occupational Health, Holzikofenweg 36, 3003 Bern, Switzerland. Electronic address: robert.pasanen-kase@seco.admin.ch.<br /><searchLink fieldCode="AU" term="%22Hopf+NB%22">Hopf NB</searchLink>; Unisanté, University Center for Primary Care and Public Health & University of Lausanne, Route de la Corniche 21, 1010 Lausanne, Switzerland. Electronic address: nancy.hopf@unisante.ch.
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