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Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma.

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Title: Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma.
Authors: Zhang Y; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Yang X; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Li X; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Zheng C; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Zeng X; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Chen J; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Gao M; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Cheng L; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Xu Z; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Chen L; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Gao Y; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Zhong J; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Huang N; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Liu X; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Liuxs6@mail.sysu.edu.cn., He K; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. hekejun3@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. hekejun3@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. hekejun3@mail.sysu.edu.cn., Zhang N; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.; Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. zhangnu2@mail.sysu.edu.cn., Wu X; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuxj76@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. wuxj76@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuxj76@mail.sysu.edu.cn.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (22), pp. 2155-2170. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+M%22">Gao M</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+N%22">Huang N</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Liuxs6@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+K%22">He K</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. hekejun3@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. hekejun3@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. hekejun3@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.; Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuxj76@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. wuxj76@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuxj76@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jun; Vol. 45 (22), pp. 2155-2170. <i>Date of Electronic Publication: </i>2026 Apr 21.
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