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Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current.

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Title: Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current.
Authors: Fleming MR; Departments of Cardiovascular Medicine and Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA. fleming.matthew@mayo.edu., Yang T; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA., Wells JA; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA., Sunthankar KI; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA., Strickland TL; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA., Blair MA; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA., Richardson TD; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA., Jahangir E; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA., Knollmann BC; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA., Roden DM; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA.; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Source: Cardio-oncology (London, England) [Cardiooncology] 2026 Apr 21; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 21.
Publication Type: Letter
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101689938 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-3804 (Electronic) Linking ISSN: 20573804 NLM ISO Abbreviation: Cardiooncology Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Editorial & Opinion
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  Data: Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current.
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  Data: <searchLink fieldCode="AU" term="%22Fleming+MR%22">Fleming MR</searchLink>; Departments of Cardiovascular Medicine and Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA. fleming.matthew@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wells+JA%22">Wells JA</searchLink>; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Sunthankar+KI%22">Sunthankar KI</searchLink>; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Strickland+TL%22">Strickland TL</searchLink>; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Blair+MA%22">Blair MA</searchLink>; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+TD%22">Richardson TD</searchLink>; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Jahangir+E%22">Jahangir E</searchLink>; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Knollmann+BC%22">Knollmann BC</searchLink>; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Nashville, Tennessee, USA.; Department of Medicine, Division of Cardiovascular Disease, Nashville, Tennessee, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%22101689938%22">Cardio-oncology (London, England)</searchLink> [Cardiooncology] 2026 Apr 21; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101689938 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2057-3804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220573804%22">20573804 </searchLink><i>NLM ISO Abbreviation: </i>Cardiooncology <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s40959-026-00485-z
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        Text: English
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      – TitleFull: Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current.
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              Text: 2026 Apr 21
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